Process for the production of a 9,3"-di-acyl derivative of a mac

Details Process for the production of a 9,3"-di-acyl derivative of a mac Process for the production of a 9,3"-di-acyl derivative of a mac

1978-08-10

1980-02-12

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 9, C07H 100

Patent

active

041884809

ABSTRACT:
A 9,3"-di-acyl derivative of a macrolide antibiotic can be readily produced by reacting a macrolide antibiotic or an acyl derivative thereof with an organic acid halide, particularly an alkanoic acid halide, in a solvent and in the presence of a molecular sieve consisting of a synthetic zeolite and then de-acylating partially the resultant acylation products by a partial hydrolysis in an aqueous alcohol to give the 9,3"-di-acyl derivative of the macrolide antibiotic.

REFERENCES:
patent: 3959256 (1976-05-01), Inouye et al.
patent: 4017516 (1977-04-01), Reimann
patent: 4017607 (1977-04-01), Inouye et al.
patent: 4090017 (1978-05-01), Sciavolino

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