Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a

Details Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a

1992-02-14

1993-11-23

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546273, A61K 3144, C07D40112

Patent

active

052644421

ABSTRACT:
This invention relates to compounds of the formula ##STR1## where R.sub.1 -R.sub.6, X and Y are as defined in the specification, which are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit and thus may be indicated in the treatment of Alzheimer's disease.

REFERENCES:
patent: 3679692 (1972-07-01), Wu
patent: 5006537 (1991-04-01), Eyyland
patent: 5039811 (1991-08-01), Effland
National Institute of Mental Health Publication No. ADM 90-1696 (1990).
James F. Flood, Brain Research, 215, pp. 177-185, 1981 "Cholinergic receptor Interactions and their effects on long-term Memory Processing".
James F. Flood, Psychopharmacology, "Memory enhancement: Supra-additive effect of Subcutaneous Cholinergic drug combinations in mice", pp. 61-67, 1985.
Paul E. Gold, Behavioral & Neural Biology, "The Use of Avoidance Training in Studies of Modulation of Memory Storage", 46, pp. 87-98, 1986.
Paul E. Gold, Animal Learning & Behavior, "Neurobiological Features Common to Memory Modulation by Many Treatments", 17, pp. 94-100, 1989.
Murray et al., Psychopharmacology (1991), 105:134-136, "Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats".

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