Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin

Details Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin

1990-10-18

1992-07-07

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514328, 546219, 546220, 546242, A61K 31445, C07D21146

Patent

active

051283476

ABSTRACT:
Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 1 to about 10 carbon atoms, aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.

REFERENCES:
patent: 5025021 (1991-06-01), Getman et al.
patent: 5026713 (1991-06-01), Getman et al.
Heiker et al., "Synthesis of D-Galacto-1-Deoxynojirimycin (1,5-dideoxy-1,5-imino-D-galactitol) Starting From 1-Deoxynojirimycin", Carbohydrate Research,203,314-318 (1990).
Schueller et al., "Synthesis of 2-Acetamido-1,2-Dideoxy-D-Galactonojirimycin (2-acetamido-1,2,5-trideoxy-1 ,5-imino-D-galactitol) From 1-Deoxynojirimycin, "Carbohydrate Research, 203,308-313 (1990).

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