Therapeutic agent for liver disease and piperazine derivatives

Details Therapeutic agent for liver disease and piperazine derivatives Therapeutic agent for liver disease and piperazine derivatives

1989-01-26

1991-12-03

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544389, A01N 4360, A61K 31495, C07D24104

Patent

active

050700898

ABSTRACT:
A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: ##STR1## wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 3, or its pharmaceutically acceptable salt is disclosed.

REFERENCES:
patent: 4112091 (1978-09-01), Nesvadba
Florvall, Dopamine .beta.-hydroxylase Inhibitors, Acta Pharm, Sucecia 1970, 7(1)7-22.
Takemoto, N-Carbodithio, Derivatives of Piperazine, CA 55:27336, Yakugaku Kankyu 33 1-6 (1961).

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