Method of inactivating reproductive filterable pathogens in fibr

Details Method of inactivating reproductive filterable pathogens in fibr Method of inactivating reproductive filterable pathogens in fibr

1985-09-13

1989-03-28

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

514 2, 514 8, 530381, 530382, A61K 3514

Patent

active

048162515

ABSTRACT:
There is disclosed a method of inactivating reproductive filterable pathogens in tissue adhesives containing fibrinogen and Factor XIII, with their biologic activity being largely preserved. In order to provide a tissue adhesive preparation of human or animal origin, which exhibits a high safety with respect to reproductive filterable pathogens and whose biologic activity is largely preserved, preparations having a minimum content of 100 units of Factor XIII/g of fibrinogen are heated in the dry state in the presence of an oxygen-free inert protective gas or under vacuum.

REFERENCES:
patent: 4297344 (1981-10-01), Schwinn et al.
patent: 4362567 (1982-12-01), Schwarz et al.
patent: 4414976 (1983-11-01), Schwartz et al.
patent: 4456590 (1984-06-01), Rubinstein
patent: 4640834 (1987-02-01), Eibl et al.
The Merch Index, 10th Ed., #7240.
Biochem. Biophys. Res. Comm. 56, 793-798, 1974; L. L. Shen et al.; "Fibrin Gel Structure; Influence of Calcium and Covalent Crosslinking on the . . . "
T. Seelich, H. Redl; "Theoretische Grundlagen des Fibrinklebers" and R. K. Schattauer Verlag, Stuttgart-N.Y., 199-208, 1980; K. Schimpf: Fibrinogen, Fibrin und Fibrinkleber.
Biomed. Res. 4, 155-160, 1983, S. Kasai, T. Kunimoto, K. Nitta-"Cross-Linking of Fibrin by Activated Factor XIII Stimulates Attachment, . . . ".
"MIR" Publishers, Moscow 1969, pp. 471-475; Rosenberg et al.-XII, International Congress on Blood Transfusion, Abstracts, USP XVI, p. 298-Fibrinogen.
Fresenius' Z. Anal. Chem. 314: pp. 567-571, E. Scholz-"Karl Fischer Reagents Without Pyridine (8), Coulometric Determination of Water".
J. Bio. Chem. 244: pp. 4406-4412, 1969, K. Weber et al.-"The Reliability of Molecular Weight Determinations by Dodecylsulfate-Polyacrylamide Gel . . . ".
Amer. J. Hyg., vol. 27: pp. 493-497, 1938, J. L. Reed et al., "A Simple Method of Estimating Fifty Per Cent Endpoints".

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