Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1975-07-23
1977-11-29
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
424180, 536 12, 536 14, 536 17, A61K 3171, C07H 1522
Patent
active
040606821
ABSTRACT:
3'-Deoxy derivatives of neamine, 6'-N-alkylneamine, kanamycin B, 6'-N-alkylkanamycin B, ribostamycin, 6'-N-alkylribostamycin and paromamine may be produced by a new process comprising reducing the 3',4'-.alpha.-anhydro derivative (namely, the 3',4'-epoxide derivative) of the aminoglycosidic antibiotics with hydrogen in an alkaline lower alkanol medium containing an alkali metal hydroxide or alkoxide dissolved therein and in the presence of a reducing catalyst such as Raney nickel. The 3',4'-.alpha.-anhydro derivative may be prepared by treating the 3'-sulfonylated derivative of the amino-protected and hydroxyl-protected neamine, 6'-N-alkylneamine, kanamycin B, 6'-N-alkylkanamycin B, ribostamycin, 6'-N-alkylribostamycin or paromamine with an alkali metal hydroxide or alkoxide in a lower alkanol to effect epoxidation between the 4'-hydroxyl group and the carbon atom substituted by the 3'-sulfonic ester group.
REFERENCES:
patent: 3868360 (1975-02-01), Daniels et al.
Pigman "The Carbohydrates", 1957, Academic Press Inc., New York, N. Y., pp. 390-395.
Akita Eiichi
Fukatsu Shunzo
Horiuchi Yukio
Miyazawa Takeo
Tsuchiya Osamu
Brown Johnnie R.
Meiji Seika Kaisha Ltd.
LandOfFree
Process for the synthetic production of 3-deoxy derivative of an does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the synthetic production of 3-deoxy derivative of an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthetic production of 3-deoxy derivative of an will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1634163