Process to obtain new mixed copper aminoacidate complexes from p

Details Process to obtain new mixed copper aminoacidate complexes from p Process to obtain new mixed copper aminoacidate complexes from p

1994-04-21

1997-02-18

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556110, 546 88, C07F 108

Patent

active

RE0354589

ABSTRACT:
This invention refers to a process to obtain new mixed copper aminoacidates complexes from phenanthrolines of an aromatic type to be used as anticancerigenic agents preferably with a therapeutic use for the treatment of liquid and solid cancerigenic tumors such as leukemia. The complexes obtained are of the [Cu (N-N) (N-O)].+-. NO.sub.3 type in which the N-N ligand corresponds to 4, 7-diphenyl-1, 10 phenanthroline and the N-O ligand preferably corresponds to one of the aminoacidates such as glycinate, alaninate, isoleucinate, leucinate, serinate and valinate. The process is characterized because it includes the following steps: making an aqueous solution based on an aliphatic alcohol and 4,7-diphenyl-1, 10 phehanthrolin react with a copper complex preferably Cu NO.sub.3 5H.sub.2 O at room temperature, and immediately after making the obtained product react in an aqueous aminoacidate solution adjusting a slightly alkaline pH.

REFERENCES:
patent: 4657928 (1987-04-01), Sorenson
patent: 4965384 (1990-10-01), Cliffton et al.
patent: 5041573 (1991-08-01), Hasegana et al.
patent: 5164367 (1992-11-01), Pickart
W. L. Kwik et al., Complexes of (2,2'-Bipyridyl) Copper(II) and (1,10-Phenanthroline) Copper(II) with Some Amino Acids, Org. Nucl. Chem., vol. 42, pp. 303-313 (1980).
W. L. Kwik et al., 2,9-Dimethyl-1,10-phenanthroline Copper(I) Complexes with Some Sulphur-containing Amino Acids, J. Chem. Soc. Dalton Trans. (1983).

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