Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-11-19
2000-05-02
Teng, Sally P.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 4352523, 43525411, 4353201, 435325, C12N 1512, C07K 14705
Patent
active
06057433&
ABSTRACT:
A gene encoding the human EP.sub.3 prostaglandin receptor has been cloned and sequenced. The protein encoded by this gene has seven transmembrane domains and is 81% homologous to the murine EP.sub.3 receptor. Two variants that differ in their carboxy terminal coding sequence, and one variant that differs in its 3' untranslated sequence only, have also been cloned. The proteins, when expressed in eukaryotic cells, are capable of binding prostaglandins and their agonists and regulating adenylate cyclase activity in response to prostaglandins.
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Gil Daniel W.
Regan John W.
Allergan Sales Inc.
Arizona Board of Regents
Baran Robert J.
Fisher Carlos A.
Teng Sally P.
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