Minimally invasive sensor

Optical waveguides – Optical waveguide sensor

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385 31, G02B 626

Patent

active

058599371

ABSTRACT:
A minimally invasive sensing device, and method for its use, is disclosed which utilizes a light-conducting fiber having a localized textured site thereon, wherein a reagent is deposited. Interaction of the reagent with an analyte specific to the reagent produces a response, such as development of a colored product, which is detectable by means of a change in characteristics of a light beam transmittable through the fiber. By means of the textured site and its increased surface area, the sensitivity of the device is greatly enhanced, such that less than 5 microliters of a fluid is needed for an analysis. The sensor is particularly useful in blood glucose determinations, requiring smaller blood samples than flat strip devices.

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Zhou et al., "Multichannel Evanescent Fluorescence Immunosensing Using Potassium and Sodium Ion-Exchanged Patterned Waveguides," Journal of Molecular Electronics, (1991 no month) 7, 135-149.

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