Substituted phenylisothioureas and processes for their preparati

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260465R, 260465E, 260468E, 260471C, 260558S, 260558R, 260559R, 260566A, 424286, 424300, 424303, 424304, 424309, 424320, 424325, 424327, 424335, C07C14940

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040051234

ABSTRACT:
N-[2-(Substituted amido)phenyl]-N'-carbonyl-S-substituted isothioureas bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenoxyphenyl)-N'-carbomethoxy-S-methylthiourea is a typical example, are prepared through the reaction of S-substituted N-(mercaptohalomethylene)carbamic acid ester and an apropriately substituted 2-aminoanilide, or through alkylation of the corresponding S-unsubstituted thiourea.

REFERENCES:
patent: 3649679 (1972-03-01), Marshall
patent: 3775463 (1973-11-01), Fischer et al.
patent: 3843715 (1974-10-01), Widdig et al.

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