Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-05
1998-12-15
Kemmerer, Elizabeth C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 435 696, 435 691, 530399, 530350, 536 235, 536 241, C07K 14475, C12N 510, C12N 121, C12N 1512
Patent
active
058495347
ABSTRACT:
A protein, Leukocyte Derived Growth Factor 2 (hereinafter LDGF2) having PDGF-like activity is described. LDGF2 reacts with PDGF receptors and possesses mitogenic and/or chemotactic activity for various cell types, particularly connective tissue cells. LDGF2 may be used as the active ingredient in therapeutic compositions, e.g. wound healing compositions, or even further may be used as an additive to cell culture media for the purpose of stimulating cell growth. The protein has a molecular weight of about 7000 daltons determined by SDS gel electrophoresis and is about 61 amino acids in length.
REFERENCES:
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Ngo et al. 1994. The Protein Folding Problem & Tertiary Structure Prediction, Merz et al, eds., Birkhauser, Boston, pp. 491-495.
Grotendorst Gary R.
Iida Naoko
DeConti, Jr. Giulio A.
Hanley Elizabeth A.
Kemmerer Elizabeth C.
University of South Florida
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