Sustained release poly (lactic/glycolic) matrices

Details Sustained release poly (lactic/glycolic) matrices Sustained release poly (lactic/glycolic) matrices

1995-11-17

1998-06-02

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424501, 5147723, A61K 950, A61K 4730

Patent

active

057595836

ABSTRACT:
This invention provides a sustained release composition comprising a PLGA matrix, a bioactive agent, and a quaternary ammonium surfactant, in which the release profile of the bioactive agent from the PLGA matrix is controlled by the concentration of the quaternary ammonium surfactant.

REFERENCES:
patent: 4675189 (1987-06-01), Kent et al.
patent: 5594091 (1997-01-01), Igari et al.
Asano et al., "In Vivo Characteristics of Low Molecular Weight Copoly(L-Lactice Acid/Glycolic Acid) Formulations with Controlled Release of Luteinizing Hormone-Releasing Hormone Agonist", J. Controlled Release , 9:111-112 (1989).
Kitchell et al., "Poly(lactic/glycolic acid) Biodegradable Drug-Polymer Matrix Systems", Methods in Enzymology, vol. 112, 436-448.
Sanders et al., "Prolonged Controlled-Release of Nafarelin, a Luteinizing Hormone-Releasing Hormone Analogue, From Biodegradable Polymeric Implants: Influence of Composition and Molecular Weight of Polymer", J. Pharm. Sci. 1986, (75)4:356-360.
Heya et al., "Effects of counteranion of TRH and loading amount on control of TRH release from copoly(dl-lactic/glycolic acid) microspheres prepared by an in-water drying method", Int. J. Pharm., 69(1991)69-75.
Sturesson et al., "Preparation of biodegradable poly(lactic-co-glycolic) acid microspheres and their in vitro release of timolol maleate", Int. J. Pharm., 89(1993)235-244.

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