Anti-cancer compositions

Details Anti-cancer compositions Anti-cancer compositions

1995-11-03

1999-04-06

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514297, A61K 3170, A61K 3144

Patent

active

058918647

ABSTRACT:
The present invention relates to an anti-cancer composition containing acridine derivatives and guanosine compounds. In the composition of the present invention, the acridine derivative and the guanosine compound are present in the weight ratio of 1:0.1-5.0, preferably 1:0.3-3.0 and more preferably 1:0.5-1.5. In the composition of the present invention, most preferably the acridine derivative is acriflavine neutral and the guanosine compound is guanosine hydrate. Although acridine derivatives and guanosine compounds used as an active ingredient in the present composition have substantially no anti-cancer effect when they are used individually, the combination of acriflavine neutral and guanosine hydrate which potentiates the effect of acriflavine neutral, i.e. the composition(AG60) according to the present invention, exhibits reduced toxicity and increased anti-cancer effect in comparison to the use of acriflavine neutral or guanosine hydrate alone.

REFERENCES:
Iigo et al., J. Pharmacobio-Dyn 5(7) 1982 pp. 515-520 (The original veterence to follow in due course).
Dyer, An index of Tumor Chemotherapy, (1949), with, pp. 10-12 and 130 ( No. 3750-3757).

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