Method for enhancing and/or accelerating immunoassay detection o

Details Method for enhancing and/or accelerating immunoassay detection o Method for enhancing and/or accelerating immunoassay detection o

1985-09-09

1988-05-10

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 29, 435 68, 4351722, 435810, 435948, 4352402, 436501, 436513, 436519, 436548, 436813, 436823, 436825, 530387, 424 85, 424 88, G01N 3353, G01N 33566, G01N 33577

Patent

active

047435437

ABSTRACT:
Detection of an identified human carcinoma tumor antigen in a pathological sample by means of a labelled monoclonal antibody specific to the determinant site on the antigen is enhanced and/or accelerated at an earlier development stage than heretofore achieved by removing a carbohydrate steric hindrance for monoclonal antibody availability to bind the antigen of the tumor for which it is specific. The carbohydrate steric hindrance for monoclonal binding to the antigen is identified as sialic acid. The method of the invention involves selective removal of sialic acid from the antigen's determinant site by enzymatic digestion using neuraminidase.

REFERENCES:
patent: 4116777 (1978-09-01), Takatsy et al.
patent: 4446122 (1984-05-01), Chu et al.
patent: 4507391 (1985-03-01), Pukel et al.
Biological Abstracts, vol. 62, 1973, Abstract No. 53599, Weiss.
Biological Abstracts, vol. 69, 1979, Abstract No. 38400, Niinobe et al.
Biological Abstracts, vol. 76, 1982, Abstract No. 11845, Miyamoto et al.
Chemical Abstracts, vol. 79, 1973, Abstract No. 63073c, Kendal et al.

Affiliated with

Also associated with

Rating

Method for enhancing and/or accelerating immunoassay detection o does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for enhancing and/or accelerating immunoassay detection o, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for enhancing and/or accelerating immunoassay detection o will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1320623