Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-12-03
1995-06-13
Martinell, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, C12P 2102, C12N 1512
Patent
active
054241987
ABSTRACT:
A method for producing tissue plasminogen activator (t-PA)in eukaroytic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.
REFERENCES:
patent: 5010002 (1991-04-01), Levinson et al.
patent: 5268291 (1993-12-01), Levinson et al.
Goeddel David V.
Kohr William J.
Levinson Arthur D.
Pennica Diane
Simonsen Christian C.
Dreger Walter H.
Genentech Inc.
Martinell James
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