Human growth hormone

Details Human growth hormone Human growth hormone

1994-05-27

1995-06-13

Low, Christopher S. F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 435 697, 4353201, 435 911, 435 914, 435 9142, 435 915, 4351723, 935 9, 935 13, 935 29, 935 56, 935 38, 935 60, 935 73, C12P 2102, G12N 1570

Patent

active

054241995

ABSTRACT:
Described are methods and means for the construction and microbial expression of quasi-synthetic genes arising from the combination of organic synthesis and enzymatic reverse transcription from messenger RNA sequences incomplete from the standpoint of the desired protein product. Preferred products of expression lack bio-inactivating leader sequences common in eukaryotic expression products but problematic with regard to microbial cleavage to yield bioactive material. Illustrative is a preferred embodiment in which a gene coding for human growth hormone (useful in, e.g., treatment of hypopituitary dwarfism) is constructed and expressed.

REFERENCES:
patent: 3853832 (1974-12-01), Li
patent: 3853833 (1974-10-01), Li
patent: 4110322 (1978-08-01), Greven et al.
patent: 4190495 (1980-02-01), Curtiss, III
patent: 4237224 (1980-12-01), Cohen
patent: 4321365 (1982-03-01), Wu et al.
patent: 4332892 (1982-06-01), Ptashne et al.
patent: 4342832 (1982-08-01), Goeddel
patent: 4356270 (1982-10-01), Itakura et al.
patent: 4363877 (1982-12-01), Goodman et al.
patent: 4366246 (1982-12-01), Riggs
patent: 4407948 (1983-10-01), Goodman et al.
patent: 4565785 (1986-01-01), Gibert et al.
patent: 4601980 (1986-07-01), Goeddel et al.
patent: 4634677 (1987-01-01), Goeddel et al.
patent: 4652525 (1987-03-01), Rutter et al.
patent: 4898830 (1990-02-01), Goeddel et al.
Boyer et al. 1969, J. Molec. Biol. 41, 459-472.
The Economist, "No More Dwarfs" 14 Jul. 1979, pp. 87-88.
Olson et al. 1981 Nature, 393, 408-411.
Newmark 1979 Nature 280, 637-638.
Backman et al. 1978, Cell 13, 65-71.
Sutcliffe 1978 Cold Spring Harbor Symp. 43, 70-90.
Crea et al. 1978, Proc. Natl. Acad. Sci. USA 75, 5765-5769.
Villa-Komaroff et al. 1978, Proc. Nat'l. Acad. Sci. USA 75, 3727-3731.
Ullrich et al. 1977, Science 196, 1313-1319.
Humphries et al. 1977, Nuc. Acd. Res. 4, 2389-2406.
Chem. Abs. 88(15), p. 249, abstract No. 101458c, (1978).
Grunstein et al. 1975, Proc. Nat'l. Acad. Sci. USA. 72, 3961-3965.
Chem. Abs. 87, p. 325, abstract No. 114458g.
Technology Rev. "The Artificial Gene", Dec. 1976, pp. 12-13.
Merck Index, 9th Edition, 1976, p. 976 entry No. 7290.
Niall, 1971, Nature New Biol. 230, 90-91.
Time, "Help from a Bug" p. 20, Jul. 1979.
Rosenblatt et al. 1976, Proc. Natl. Acad. Sci. USA 73, 2747-2751.
Enzyme Nomenclature: Recommendations (1978) of the Nomenclature Committee of the International Union of Biochemistry--Academic Press, Inc., N.Y. (1979) pp. 296-348.
Methods in Enzymology, vol. XIX Proteolytic Enzymes--Eds., Gertrude E. Perlmann, Laszlo Lorand, Academic Press, N.Y. (1970) pp. v.-ix.
Methods in Enzymology, vol. XLV Proteolytic Enzymes--Part B--Ed. Laszlo Lorand, Academic Press, N.Y. (1976) pp. v.-ix.
Mammalian Proteases: A Glossary and Bibliography, vol. 2 Exopeptidases--Academic Press, N.Y. by McDonald, et al. (1986) complete book, pp. v.-357.
Bukhari, et al., "Nature New Biol.", 243:238-241 (1973 Jun. 20).
Cheng, et al., "Gene", 14:121-130 (1981).
Goldberg, et al., "Ann. Rev. Biochem.", 45:747-803 (1976).
Goldberg, et al., "Studies of the Selectivity and Mechanisms of Intracellular Protein Degradation", in Proteolysis and Physiological regulation, 313-317 (1976).
Goldschmidt, "Nature", 228:1151-1154 (1970 Dec. 19).
Kemshead et al., "Eur. J. Biochem.", 45:540 (1974).
Platt et al., "Nature", 228:1154-1156 (1970 Dec. 19).
Prouty et al., "J. Biol. Chem.", 350:1112-1122 (1975).
Simon et al., "PNAS USA", 80:2059-2062 (Apr. 1983).
Kostyo et al., "Metabolism", 25:105-124 (1976).
Lewis et al., "Endo", 101:1587-1603 (1977).
Lewis et al., "J. Biol. Chem.", 253:2679-2687 (1978 Apr. 25).
Mills et al., "Endoctrinol.", 107:391-399 (1980).
Singh et al., "Endo", 94:883-891 (1974).
Seeburg et al., "Nature", 270:486-494 (1977 Dec. 8).
Goodman, Proceedings of Alfred Benzon Symposium 13, 16-20 Aug., 1978, Copenhagen, pp. 179-190 (1978).
Document filed in the High Court of Justice, Chancery Division, Patents Court, United Kingdom related to purported contents of Gilbert presentation at the 16th Insulin Symposium.
Anonymous summary of proceedings, 16th Insulin Symposium, Gilbert Presentation, 24-25 May 1976.
Backman et al., "PNAS USA", 73:4174-4178 (Nov. 1976).
Burrell et al., "Nature", 279:43-47 (1979).
Chain, "Biotechnology Appl. of Proteins and Enzymes, Academic Press (New York 1977) pp. 1-17 (1977).
Fraser et al., "PNAS USA", 75:5936-5940 (Dec. 1978).
Goeddel, Transcript of Lecture at Miles Symposium on Jul. 12, 1979.
Itakura et al., 26th Int'l. Congress of Pure and Applied Chemistry (ABS) Sep. 4-10, 1977, p. 337 (1977).
Mercereau-Puijalon et al., "Nature", 275:505-510 (Oct. 1978).
Murray et al., "Hoppe Seylers Z. Physiol. Chem.", 360:1036 (1979).
Pasek et al., "Nature", 282:575-579 (1979).
Sverdlov et al., "Sov. J. Bioorganic Chem.", 5:837-839 (Jul. 1979).
Ullrich et al., Proc. Symposium Proinsulin, Insulin and C-Peptide Tokushima, pp. 20-26, Jul. 12-14 1978 (1978).
Higuchi et al., "PNAS USA", 73:3146-3150 (1976).
Itakura et al., "J. Biol. Chem.", 250:4592-4600 (1975).
Itakura et al., "J. Amer. Soc.", 97:7327-7332 (1975).
Narang, "Can. J. Biochem.", 55:1125-1133 (1977).
Scheller et al., "Science", 196:177-180 (1977 Apr. 8).
Szekely, "Nature", 263:277-278 (1976).
Li et al., J. Am. Chem. Soc., vol. 92, pp. 7608-7609 (1970).
Roberts et al., Proc. Natl. Acad. Sci. USA, vol. 76, No. 2, pp. 760-764 (Feb. 1979).
Itakura et al., Science, vol. 198, pp. 1056-1063, Dec. 9, 1977.
Bolivar et al., Gene 2, pp. 95-113 (1977).
Chang et al., Nature vol. 275, pp. 617-624 (Oct. 1978).
Goeddel et al., PNAS 76, pp. 106-110 (1979).
Goedell et al., Nature, vol. 281, pp. 544-548 (Oct. 1979).
Klenow et al., PNAS vol. 65, pp. 168-175 (Jan. 1970).
Kornberg, DNA Synthesis, pp. 87-88, pub. by W. H. Freeman & Co., (1974).
Marians et al., Nature vol. 263, pp. 744-748 (Oct. 1976).
Mayam et al., PNAS, vol. 74, pp. 560-564 (Feb. 1977).
Polisky et al., PNAS 73:11, pp. 3900-3904 (1976).
Razin et al., PNAS, vol. 75, pp. 4268-4270 (Sep. 1978).
Seeburg et al., Nature, vol. 276, pp. 795-798 (Dec. 1978).
Shine et al., Nature, vol. 285, pp. 456-461 (Jun. 1980).
Wickens et al., The J. of Biological Chemistry, vol. 253, No. 7, pp. 2483-2495 (1978).
Freifelder, Molecular Biology, Science Books International, pp. 508-511, 1983.
The Merk Index, Tenth Edition, pp. 1246-1247, 1983.
Martial et al., Science, vol. 205, pp. 456-461 (Aug. 10, 1980).

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