Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1984-03-05
1985-03-26
Phillips, Delbert R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07C10352
Patent
active
045072353
ABSTRACT:
Peptides having the carboxyl terminated sequence of the pancreozymin-cholstokinin 25-33 modified such that the amino acid group 25 carries a strongly basic group, the amino acid group 28 exhibits a hydrophilic character similar to that of the hydroxyamino acids and the amino acid group 31 exhibits a strongly hydrophobic character similar to that of amino acids with aliphatic side chains, and in particular nonapeptides having the sequence H--X--Asp--Tyr(SO.sub.3 H)--Y--Gly--Trp--Z--Asp--Phe--NH.sub.2 wherein X is arginine, homoarginine, norarginine, N.sub..epsilon.,N.sub..epsilon. -dialkyllysine, N.sub..delta. or N.sub..delta. -dialkyl-ornithine, Y is threonine, serine or hydroxy-proline and Z is norleucine, leucine, norvaline or .alpha.-amino-butyric acid, possess pronounced pancreozymin activity and can be employed in pharmaceutical preparations for controlling the function of the gall bladder and for controlling the enzyme secretion of the pancreas. Tyrosine-O-sulfate-barium salt and its N-acyl derivatives can be used as intermediate products for the preparation of peptides. For introducing the amino acid group 27 an N-acyltyrosine is reacted with an excess of pyridine--SO.sub.3 in a polar organic solvent, the resulting solution is extracted with water, the barium salt of the N-acyl-tyrosine-O-sulfate is precipitated from the aqueous phase by addition of a soluble barium compound, possibly the acyl group is split off in conventional manner, and the resulting tyrosine-O-sulfate-barium salt or its acyl derivative are processed employing the usual methods of peptide synthesis.
REFERENCES:
patent: 3038908 (1962-06-01), Beereboon
patent: 3579494 (1971-05-01), Ondetti et al.
patent: 3705140 (1972-12-01), Bernardi et al.
patent: 3723406 (1973-03-01), Ondetti et al.
patent: 3734946 (1973-05-01), Ondetti
patent: 3778429 (1973-12-01), Ondetti et al.
patent: 4330466 (1982-05-01), Yanaihara et al.
Chem. Abstr. vol. 91, (1979), 175731.
Chem. Abstr. vol. 92, (1980), 147192.
Chem. Abstr. vol. 95, (1981), 81480.
Chem. Abstr. vol. 95, (1981), 169774.
Chem. Abstr. vol. 85, (1976), 160525.
Chem. Abstr. vol. 95, (1981), 7776.
Chem. Abstr. vol. 94, (1981), 66091.
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.v.
Phillips Delbert R.
LandOfFree
Method for preparing peptides and intermediate products does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for preparing peptides and intermediate products, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preparing peptides and intermediate products will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1293364