Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and a

Details Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and a Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and a

1999-07-27

2000-08-29

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 82, 546 83, 546 84, A61K 3144, C07D47102, C07D48702, C07D51302, C07D51702

Patent

active

061109290

ABSTRACT:
Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

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