Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-05-13
1996-05-07
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514252, 514382, 514461, 514473, 544224, 544238, 544239, 544240, 544241, 544333, 544335, 544405, 546214, 546344, 548131, 548132, 548133, 548143, 548144, 548127, 548128, 548179, 548214, 548217, 548203, 548235, 548247, 548252, 548253, 548255, 5482622, 5483154, 548517, 549 59, 549472, 549475, 549476, 549448, 549478, 549479, 549491, 549497, 549498, 549499, 549500, 549501, 549504, A61K 3150, C07D41312, C07D23708, C07D23712
Patent
active
055146791
ABSTRACT:
Compounds of the formula ##STR1## wherein: R.sub.1 and R.sub.2 are independently hydrogen, halo, alkyl, alkenyl, alkoxy, hydroxy, hydroxyalkyl, hydroxyhaloalkyl, alkoxyalkyl, alkylthioalkynyl, hydroxyalkoxy, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy or cyanomethyl, nitro, difluoromethyl, trifluoromethyl or cyano;
Y is alkylene of 3 to 9 carbon atoms;
R.sub.3 and R.sub.4 are independently hydrogen, alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, hydroxyhaloalkyl, alkoxyalkyl, hydroxyalkoxy, alkylthioalkyl, alkanoyl, alkanoyloxy, alkylsulfinylalkyl, alkylsulfonylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy, cyanomethyl, fluoroalkyl, cyano, phenyl, alkynyl, alkene, or halo;
R.sub.5 is alkoxycarbonyl, alkyltetrazolyl, phenyl or a heterocycle;
or a pharmaceutically acceptable acid addition salts thereof; N-oxides thereof, are useful as antipirconaviral agents.
REFERENCES:
patent: 4857539 (1989-08-01), Diana et al.
patent: 4861791 (1989-08-01), Diana et al.
patent: 5242924 (1993-09-01), Diana et al.
Aldous David J.
Bailey Thomas R.
Diana Guy D.
Nitz Theodore J.
Bernhardt Emily
DuPont Paul E.
Hake Richard A.
Sterling Winthrop Inc.
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