Thrombosis agent

Details Thrombosis agent Thrombosis agent

1995-03-27

1998-07-07

Lankford, Jr., Leon B.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 424529, 424530, 424531, A61K 3848, A61K 3514, A61K 3516

Patent

active

057764522

ABSTRACT:
The invention provides compositions having thrombolytic effects, and comprise plasmin and a plasminogen activator. Such compositions can be administered locally or systemically. The invention also provides simple and safe therapies for thrombotic states and prevention of such states.

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patent: 4774087 (1988-09-01), Wu et al.
patent: 4808405 (1989-02-01), Smith et al.
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patent: 5304383 (1994-04-01), Eibl et al.
patent: 5520912 (1996-05-01), Eibl et al.
Gonzales-Gronow et al., "Mechanism of Activation of Human Plasminogen by the Activator Complex, Streptokinase Plasmin", Jul. 25, 1977, pp. 1090-1094.
V. V. Kakkar et al., "Intermittent Plasminogen--Streptokinase Treatment of Deep Vein Thrombosis", 1988, pp. 127-138.
A. Schoppmann et al., "Production and Quality Assurance of LYS-Plasminogen Steam Treated", Feb. 2, 1988, pp. 157-163.
Yumiko Takada et al., "The Conversion of Streptokinase--Plasminogen Complex to SK-Plasmin Complex in the Presence of Fibrin or Fibrinogen", Jul. 2, 1989, pp. 133-139.

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