Method and means for detection of adrenal metabolic activity

Details Method and means for detection of adrenal metabolic activity Method and means for detection of adrenal metabolic activity

1988-08-02

1990-06-26

Locker, Howard J.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 128659, A61K 4902

Patent

active

049370677

ABSTRACT:
The metabolic activity of the adrenal gland can be monitored by intravenously injecting an infusate composed of low density lipoproteins labelled with a radioisotope that is suitable for extracorporeal imaging and subsequently measuring the intensity of radioisotope accumulation in organs of the body. By monitoring the accumulation at the sites of the adrenal glands, the metabolic activity can be localized and the level of activity can be assessed.

REFERENCES:
patent: 4215045 (1980-07-01), Knapp
patent: 4323546 (1982-04-01), Crockford et al.
patent: 4421735 (1983-12-01), Haber et al.
patent: 4490350 (1984-12-01), Zolle
patent: 4528177 (1985-07-01), Molloy et al.
patent: 4647445 (1987-03-01), Lees
Kovanen et al., J. Biol. Chem., vol. 254, No. 12, 1979, pp. 5498-5505.
Counsell et al., Biochim. Biophys. ACTA, 750, 1983, pp. 497-503.
Roheim et al., Biochim. Biophys. ACTA, 248, 1971, pp. 315-329.
B. Shapiro et al., Clinical Experience With .sup.75 Se Selenomethylcholesterol Adrenol Imaging (1981) 15, 19-27.
Richard J. Blair et al., Radiolabeled Cholesterol as an Adrenal Scanning Agent, 176-182.
William H. Beierwaltes et al., Adrenal Imaging Agents: Rationale, Synthesis, Formulation and Metabolism, vol. VIII, No. 1 (1978).
D. Roger Illingsworth, Adrenal Cortical Function in Homozygous Familial Hypercholesterolemia, vol. 30, No. 11 (Nov.), 1983.
Ann M. Lees and Robert S. Lees, Low Density Lipoprotein Degredation by Mononuclear Cells from Normal and Dyslipoproteinemic Subjects, vol. 80, pp. 5098-5102, Aug. 1983, Medical Sciences.
Dr. Jonathan L. Isaacson, 1984 Abstract Form For Scientific Papers and Scientific Exhibits Society of Nuclear Medicine 31st Annual Meeting, Los Angeles, CA, June 5-8, 1984.

Affiliated with

Also associated with

Rating

Method and means for detection of adrenal metabolic activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and means for detection of adrenal metabolic activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and means for detection of adrenal metabolic activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1124712