Diphenylhydantoin derivatives

Details Diphenylhydantoin derivatives Diphenylhydantoin derivatives

1978-12-07

1980-03-18

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548314, C07D23372, C07D23378

Patent

active

041940482

ABSTRACT:
Reagents for use in binding assays, particularly immuno-assays, to determine diphenylhydantoin and for preparing reagents employed in such assays, including .beta.-galactosyl-umbelliferone-diphenylhydantoin conjugates, diphenylhydantoin immunogens, and N.sup.1, N.sup.3 and .omicron.-phenyl derivatives of diphenylhydantoin for preparing same. N.sup.1 and N.sup.3 -.omega.-aminoalkyl and .omicron.-(.omega.-aminoalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to a .beta.-galactosyl-umbelliferone derivative to form labeled conjugates useful in homogeneous or heterogeneous binding assays. N.sup.1 and N.sup.3 -.omega.-carboxyalkyl and .omicron.-(.omega.-carboxyalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to an immunogenic polyamino acid to form immunogen conjugates against which diphenylhydantoin-specific antibodies can be raised.

REFERENCES:
patent: 2242775 (1941-05-01), Bywater
Blade Font Chem. Abst. 1975, vol. 83, No. 179062k.
Shaffer et al. J. Med. Chem. 1968, vol. 11, pp. 462-466.
Chemical Abstracts Chemical Substance Index, I-Po, Jan.-Jun., 1977, p. 2619CS, first column.
Rowell et al. Chem. Abst. 1977, vol. 86, No. 104290m.
Vergauwe Chem. Abst. 1969, vol. 71, No. 61396w.

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