Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-11-07
2000-05-09
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 435369, 536 235, C12N 510, C12N 1512, C12N 1579, C12P 2102
Patent
active
060602759
ABSTRACT:
A new class of mammalian sprouty proteins is disclosed. The proteins are characterized by an amino acid sequence whose cysteine-rich region has at least 40% sequence identity with SEQ ID NO:17 in the human sprouty 2 protein whose full length sequence is identified by SEQ ID NO:8. Also disclosed are (i) a pharmaceutical preparation containing a sprouty protein, (ii) a DNA sequence encoding the protein, (iii) vector and gene therapy compositions containing the DNA coding sequence, and (iv) methods of detecting a condition characterized by, or risk factor associated with, abnormal levels of active mammalian sprouty protein in a mammalian subject.
REFERENCES:
Database Dissabs on STN, AN 97:50427. UMI AAR9723363, Hacohen, N. et al. Branching Morphogenesis in the Drosophila Tracheal System (sprouty, branchless, cell differentiation), Diss. Abstr. Int. B. 1997, vol. 58, No. 2B, p. 517.
Database Dissabs on STN, AN 97:77511. UMI AAR9801196, Kramer, K.S. Cell Fate Determination in the Compound Eye of Drosphila Melanogaster: the Roles of Seven-up and Sprouty (vision, photoreceptor, cones), abstract, Diss. Abstr. Int. B. vol. 58, No. 7B, p. 3444.
Hacohen, N., et al., "sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways," Cell, 92: 253-263 (1998).
Cross et al. (Mar. 1994) Purification of CpG islands using a methylated DNA binding column. Nature Genetics 6:236-244.
Hillier et al. (Jun. 2, 1995) EST # 156055. GenBank EST. Accession No. R72442. Accessed May 18, 1998.
Hillier et al. (Apr. 10, 1996) EST # 278548. GenBank EST. Accession No. N98688. Accessed May 18, 1998.
Hacohen Nir
Krasnow Mark A.
Schwartzman Robert A.
Steel Diana M.
The Board of Trustees of the Leland Standord Junior University
Vincent, Esq. Matthew
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