Antihypertensive thieno-isoxazoles and -pyrazoles

Details Antihypertensive thieno-isoxazoles and -pyrazoles Antihypertensive thieno-isoxazoles and -pyrazoles

1985-10-24

1988-03-01

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514379, 514405, 514415, 544368, 544371, 548242, 548370, A61K 31495, C07D41314, C07D48702

Patent

active

047286512

ABSTRACT:
There are described compounds of the formula ##STR1## where X is O or NR, R being hydrogen or loweralkyl; R.sub.1 is hydrogen; and R.sub.2 is loweralkyl, arylloweralkyl, aryloxyloweralkyl or loweralkyl substituted with ##STR2## or alternatively --NR.sub.1 R.sub.2 taken together is ##STR3## R.sub.3 being arylloweralkyl or a pharmaceutically acceptable acid addition salt thereof, which are useful as ocular or systemic antihypertensive agents.

REFERENCES:
patent: 3655661 (1972-04-01), Wasson
patent: 4387100 (1983-06-01), Machin
patent: 4409231 (1983-10-01), Stenzel et al.
patent: 4428950 (1984-01-01), Franke et al.
patent: 4558125 (1985-12-01), Iwao et al.

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