Apparatus for the chemical synthesis of oligonucleotides

Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition – Sensed condition is operating time and control is operation...

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422 62, 422134, 422191, 422209, 435287, 435289, 436 89, 935 88, C07K 104

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047285028

ABSTRACT:
Apparatus for carrying out a multiplicity of different sequential chemical syntheses on solid-supports simultaneously comprises a multiplicity of complementary support plates each formed with a reaction chamber opening through the plate and containing the solid-support together with at least one by-pass channel through the plate. The by-pass channel or channels and reaction chamber are disposed equi-angularly and at the same radial distance about an axis of the plate. The plates are rotatably supported in compression in face to face contact between end plates complementary to the plates and each formed with a blank position and passages for at least one reactant stream. Means is provided for independently rotating each plate whereby each reaction chamber of each plate may independently be isolated or positioned in the or a selected reactant stream.

REFERENCES:
patent: 2792122 (1957-05-01), Munch et al.
patent: 3490879 (1970-01-01), Urban
patent: 4152391 (1979-05-01), Cabrera
patent: 4159950 (1979-07-01), Hayashida et al.
patent: 4267045 (1981-05-01), Hoof
patent: 4507977 (1985-04-01), Cabrera
patent: 4517338 (1985-05-01), Urdea
"Rapid Synthesis of Oligodeoxyribonucleotides VII. Solid Phase Synthesis . . . Kieselguhr-Polyamide Support", by M. J. Gait et al., Nucleic Acids Research, vol. 10, No. 20, Oct. 25, 1982.

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