N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compo

Details N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compo N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compo

1999-12-09

2000-12-26

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514428, 548528, 548530, A61K 31401, A61P 548, C07D20712, C07D20714

Patent

active

061660639

ABSTRACT:
The present invention relates to a compound of formula (I) ##STR1## wherein R is substituted adamantyl; and n is 0 to 3; in free form or in acid addition salt form. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.

REFERENCES:
patent: 4661512 (1987-04-01), Laruelle et al.
Li, et al. Archives of Biochemistry and Biophysics, vol. 323, No. 1, pp. 148-154 (1995).
Li, et al. Journal of Neurochemistry, vol. 66, pp. 2105-2112 (1996).
Yamada, et al. Bulletin of the Chemical Society of Japan, vol. 50, No. 7, pp. 1827-1830 (1977).
Yamada, et al. Bulletin of the Chemical Society of Japan, vol. 51, No. 3, pp. 878-883 (1978).
Derwent Abstract 95: 302548. (1994).
Derwent Abstract 84: 177689. (1983).
Derwent Abstract 96: 116353. (1994).
Kaspari, et al. Biochimica et Biophysica, vol. 1293, pp. 147-153 (1996).
Ashworth, et al. Bioorganic and Medicinal Chemistry Letters, vol. 6, No. 10, pp. 1163-1166 (1996).
Coutts, et al. J. Med Chem., vol. 39, pp. 2087-2094 (1996).
Deacon, et al. Diabetes, vol. 44, pp. 1126-1131 (Sep. '96).
Ashworth, et al. Bioorganic and Medicinal Chemistry Letters, vol. 6, No. 22, pp. 2745-2748 (1996).
Augustyns, et al. Eur J. Med. Chem., vol. 32, pp. 301-309 (1997).
Hughes, et al. Biochemistry, vol. 38, pp. 11597-11603 (1999).

Affiliated with

Also associated with

Rating

N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-995400