Combination of atovaquone with proguanil for the treatment of pr

Details Combination of atovaquone with proguanil for the treatment of pr Combination of atovaquone with proguanil for the treatment of pr

1999-10-01

2000-12-26

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514565, 514682, 514895, A61K 3115, A61K 31155

Patent

active

061660469

ABSTRACT:
The invention relates to combinations of atovaquone and proguanil, their use in the treatment and prophylaxis of parasitic infections such as protozoal parasitic infections, e.g., malaria and toxoplasmosis, and infections caused by P. carinii and their use in the manufacture of medicaments for the treatment and/or prophylaxis of such infections. The combinations can conveniently be administered in a single pharmaceutical formulation. Preferably, atovaquone and proguanil are administered in a potentiating ratio so that they act in synergy.

REFERENCES:
patent: 3347830 (1967-10-01), Rogers
patent: 3367742 (1968-02-01), Sarett
patent: 3674872 (1972-07-01), Rheimer et al.
patent: 4981874 (1991-01-01), Latter et al.
patent: 5053418 (1991-10-01), Latter et al.
patent: 5053432 (1991-10-01), Hudson et al.
patent: 5206268 (1993-04-01), Latter et al.
patent: 5310762 (1994-05-01), Latter et al.
Atovaquone in Phase II trials in Thailand. R & D Focus Drug News. Feb. 24, 1992. DRUGNL Assession No. 92:133.
Parasitol. Today, vol. 8, No. 8, pp 252-255, C.P.J. Ash "Fourth malaria meeting" Aug. 1992.
Parasitol. Today, vol. 9, No. 2, pp 66-68, A.T. Hudson "Atovaquone--a novel broad-spectrum anti-infective drug" Feb. 1993.
Abstract and Poster by M. Pudney et al VIII International Congress of Protozoology, Jul. 10-17, Tsukuba, Japan 1992.
Wofsy, pp 377-401, Chapter 36, 1986.
Fieser et al vol. 70, pp 3156-3165, 1948.
Hughs, Parasitology Today, vol. 3, No. 11, pp. 332-335, 1887.
Parsons, 10 pages, issued Aug. 7, 1989.
Discriminant Analysis and Structure-Activity Ralationships 1. Naphthoquinone; J. Med. Chem. vol. 21; No. 4, 1978 pp 369-374.
Role of the Naphthoquinone Moiety in the Biological Activities of Sakyomicin A: J. Antibiot. vol. 39; No. 4, 1986; pp 557-563.
Inhibition of Thioredoxin Reductase (E.C. 1.6.4.5) by Antitumor Quinones; Free Rad. Res. Commun. vol. 8; No. 4-6; 1990; pp 365-372.
Shargel et al Applied Biopharmaceutics and Pharmacokinetics, 2.sup.nd Edition Appleton-Century-Crofts, 1985.

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