Diaminopuridine-containing thiourea inhibitors of herpes viruses

Details Diaminopuridine-containing thiourea inhibitors of herpes viruses Diaminopuridine-containing thiourea inhibitors of herpes viruses

1999-11-22

2000-12-26

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514359, 514430, 514438, 5462687, 5462681, 5462697, 5462711, 5462727, 548127, 548128, 548134, 548184, A61K 314427, A61K 314436, A61K 314439, C07D41712, C07D27720

Patent

active

061660280

ABSTRACT:
Compounds of the formula ##STR1## are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

REFERENCES:
patent: 5593993 (1997-01-01), Morin et al.
Roizman, B., Herpesviridaie. 2221-2230 (1996).
Whitley, R.J., Herpes Simplex Viruses, 2297-2342 (1996).
Arvin, A., Varicella-Zoster Virus, 2547-2585 (1996).
Rickinson, A.B. et al., Epstein-Barr Virus, 2397-2446 (1996).
Britt, W.J. et al., Cytomegalovirus, 2493-2523 (1996).
Pellet, P.E. et al., Human Herpesvirus, 6, 2587-2608 (1996).
Frenkel, N. et al., Human Herpesvirus, 7, 2609-2622 (1996).
Neipel, F. et al., J. Virol., 71, No. 6, 4187-4192 (1997).
Bron, D. et al., Exp. Opin. Invest, Drugs, 5(3), 337-344 (1996).
Crumpacker, C., New England J. Med., 335, 721-729 (1996).
Sachs, S. et al., Exp. Opin. Invest. Drugs, 5(2), 169-183 (1996).

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