Process for the preparation of tetralone imines for the preparat

Details Process for the preparation of tetralone imines for the preparat Process for the preparation of tetralone imines for the preparat

1998-04-23

2000-04-25

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564308, C07C24902

Patent

active

06054614&

ABSTRACT:
4-(3,4-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene-methylamine and related analogs are prepared from .alpha.-tetralone by a facile three-step process. This compound is the required intermediate to prepare sertraline, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamin e. Sertraline has selective serotonin uptake inhibitor activity making it a valuable antidepressant pharmaceutical product.

REFERENCES:
patent: 4536518 (1985-08-01), Welch, Jr. et al.

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