Antitumor cyclopentnaphthoquinone and cyclopentanthraquinone der

Details Antitumor cyclopentnaphthoquinone and cyclopentanthraquinone der Antitumor cyclopentnaphthoquinone and cyclopentanthraquinone der

1993-03-12

1995-12-19

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548961, C07D20326

Patent

active

054769523

ABSTRACT:
The present invention provides compounds having the structure: ##STR1## or having the structure: ##STR2## The present invention also provides a pharmaceutical compostion containing the compounds, methods of synthesizing the compounds, as well as methods of inhibiting growth of tumor cells and of treating a subject having a disease characterized by the proliferation of tumor cells.

REFERENCES:
Moore, "Bioactivation as a Model for Drug Design Bioreductive Alkylation," Science, Aug., 1977; vol. 197, pp. 527-532.
Tomasz, et al., "Reductive Metabolism and Alkylating Activity of Mitomycin C Induced by Rat Liver Microsomes", Biochemistry, Aug., 1981; vol. 20, pp. 5056-5061.
Tomasz, et al., "Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA", Science, Mar., 1987, vol. 235, pp. 1204-1208.
Archer, "The Chemotherapy of Schistosomiasis", Ann. Rev. Pharmacol. Toxicology 1985; vol. 25, pp. 485-508.
Koyama, et al., "Intercalating Agents with Covalent Bond Forming Capability. A Novel Type of Potential Anticancer Agents. 2. Derivatives of Chrysophanol and Emodin", J. Med. Chem., Jul., 1989; vol. 32, pp. 1594-1599.
Brown, et al., "Studies on Compounds Related to Auxin-a and Auxin-b. Part III. The Preparation and Properties of the cycloPentenyl Analogue of Auxin-b Lactone", J. Chem. Soc., Nov., 1950; pp. 3634-3641.
Krow, et al., "A Simple Synthesis of 4-Cyclohexene-1,2-cis-Diol and Its Use as the Precursor of a Functionalized Cyclohexanone Synthon", Org. Prepns. and Proceds. Int., Dec., 1977; vol. 9, pp. 285-288.
McCasland et al., "Synthesis of the Five Diastereomeric 1,2,4,5-Cyclohexanetetrols. Nuclear Magnetic Resonance Configurational Proofs", J. Org. Chem., Apr., 1963; vol. 28, pp. 894-900.
Caine et al., "Diels-Adler Reactions of 2-Carbomethoxy-4, 4-Dimethylcyclopentenone", Tetrahedron Lett., 1983; vol. 24, pp. 1353-1356.
Kinoshita et al., "Mitomycin Derivatives. 1. Preparation of Mitosane and Mitosene Compounds and their Biological Activies", J. Med. Chem., Feb., 1971; vol. 14, pp. 103-109.
Archer et al., "Preparation and Antischistosomal and Antitumor Activity of Hycanthone and Some of its Congeners. Evidence for the Mode of Action of Hycanthone", J. Med. Chem., Jan. 1988; vol. 31, pp. 254-260.

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