Ligands of thrombin

Details Ligands of thrombin Ligands of thrombin

1992-11-06

1995-12-19

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 221, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

054767660

ABSTRACT:
Methods are described for the identification of nuclei acid ligand solutions to thrombin. The present invention utilizes the SELEX (Systematic Evolution of Ligands for EXponential enrichment) method for identifying and preparing RNA ligands to thrombin. Further included in the present invention are modified nucleotide sequences based on the sequences of the RNA ligands identified. The modified RNA ligands to thrombin exhibit increased in vivo stability.

REFERENCES:
patent: 5118672 (1992-06-01), Schinazi et al.
Bock et al., Nature 355:564-566 (Feb. 6, 1992).
Bar-Shavit et al. (1983) Science 220:728.
Bass and Cech (1984) Nature 308:820.
Berndt and Phillips (1981) in Platelets in Biology and Pathology, J. L. Gordon, ed. (Amsterdam:Elsevier/North-Holland Biomedical Press), pp. 43-74.
Carey et al. (1983) Biochemistry 22:2601.
Chen and Buchanan (1975) Proc. Natl. Acad. Sci. USA 72:131.
Chen et al. (1976) Exp. Cell Res. 101:41.
Daniel et al. (1986) J. Biol. Chem. 261:9579.
Eidt et al. (1989) J. Clin. Invest. 84:18.
Guschlbauer et al. (1977) Nucleic Acids. Res. 4:1933.
Hanson and Harker (1988) Proc. Natl. Acad. Sci. USA 85:3184.
Hattori et al. (1989) J. Biol. Chem. 264:7768.
Hobbs et al. (1973) Biochem. 12:5138.
Joyce (1989) in RNA:Catalysis, Splicing, Evolution, Belfort & Shub (Eds.) Elsevier, Amsterdam, pp. 83-87.
Kacian et al. (1972) Proc. Natl. Acas. Sci. USA 69:3038.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Levisohn and Spiegelman (1968) Proc. Natl. Acad. Sci. USA 60:866.
Marx (1992) Science 256:1278.
Mills et al. (1973) Science 180:916.
Mills et al. (1967) Proc. Nat.. Acad. Sci. USA 58:217.
Pieken et al. (1991) Science 253:314.
Rich et al. (1984) Ann. Rev. Biochem. 53:791.
Robertson and Joyce (1990) Nature 344:467.
Romaniuk et al. (1987) Biochemistry 26:1563.
Saffhill et al. (1970) J. Mol. Biol. 51:531.
Shibahara et al. (1987) Nucleic Acids. Res. 15:4403.
Schimmel (1989) Cell 58:9.
Tuerk et al. (1990) J. Mol. Biol. 213:749.
Tuerk et al. (1988) Proc. Natl. Acad. Sci. USA 85:1364.
Ulenbeck et al. (1983) J. Biomol. Structure Dynamics 1:539.
Vu et al. (1991) Cell 64:1057.
Witherell and Uhlenbeck (1989) Biochemistry 28:71.
Yarus (1988) Science 240:1751.
Zimmerman et al. (1986) Ann. N.Y. Acad. Sci. 485:349.

Affiliated with

Also associated with

Rating

Ligands of thrombin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ligands of thrombin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ligands of thrombin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-991541