Hybridoma cell lines and monoclonal antibodies to theophylline

Details Hybridoma cell lines and monoclonal antibodies to theophylline Hybridoma cell lines and monoclonal antibodies to theophylline

1982-08-09

1985-06-18

Shapiro, Lionel M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435 7, 435 68, 435240, 435948, 436548, 424 85, 260112B, A23J 100, C12P 2100, C12N 500, G01N 3354

Patent

active

045240256

ABSTRACT:
Monoclonal antibodies to theophylline having 5% or less cross-reactivity with caffeine and the continuous hybrid monoclonal cell lines for their production are provided. These antibodies are useful in a particle-enhanced turbidimetric inhibition immunoassay for theophylline.

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patent: 4401765 (1983-08-01), Craig et al.
Boettscher, Irmgard et al., "Permanent Production of . . . Napten Spec." Chemical Abstracts vol. 91, No. 82053x, 1980.
Kohler, et al., Nature, 256, 495, (1975), Current Topics in Microbiology and Immunology, vol. 81, F. Melchers, M. Potter, and N. Warner, Ed., Springer-Verlag, 1978.
Monoclonal Antibodies, R. Kennett, T. McKearn and K. Bechtol, Ed., Plenum Press 1980.
Mudgett-Hunter et al., Federal Proceedings, 39,928, (1980).
Makela et al., Scand. J. Clin. Lab. Invest., 41,75, (1981).

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