Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-03-26
1998-05-12
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514642, A61K 3800, A01N 3718
Patent
active
057504954
ABSTRACT:
A method for treating polycystic kidney disease in an individual in need thereof. This method includes identifying a mammal having a cystic disease and administering to the mammal a pharmacologically effective anti-cystic amount of TNF-.alpha. or an agent which stimulates TNF-.alpha. production in vivo. The agent is administered in a pharmacologically acceptable carrier, excipient or diluent.
REFERENCES:
Woo et al., "Taxol inhibits progression of congenital polycystic kidney disease", Nature, vol. 368, Apr. 21, 1994, pp. 750-753.
T. Akimoto, et al. (1994) "Antitumor Effect of DT-5641a, a Synthetic Low-Toxicity Lipid a Analog, Involves Endogenous Tumor Necrosis Factor Induction Subsequent to Macrophage Activation", Int. J. Immunopharmac., 16(11):887-893.
E.D. Avner, et al. (1992) "Abnormal Sodium Pump Distribution During Renal Tubulogenesis in Congenital Murine Polycystic Kidney Disease", Proc. Natl. Acad. Sci. U.S.A., 89:7447-7451.
B. Beutler, et al. (1994) "Unraveling Function in the TNF Ligand and Receptor Families", Science 264:667-668.
A.P. Bollon, et al. (1988) "Human Cytokines, Tumor Necrosis Factor, and Interferons: Gene Cloning, Animal Studies, and Clinical Trials", Journal of Cellular Biochemistry, 36:353-367.
E.A. Carswell, et al. (1975) "An Endotoxin-Induced Serum Factor that Causes Necrosis of Tumors", Proc. Nat. Acad. Sci. U.S.A., 72(9):3666-3670.
B.D. Cowley, et al. (1991) "Elevated Proto-Oncogene Expression in Polycystic Kidneys of the C57BL/6J (CPK) Mouse", J. Am. Soc. Nephrol., 1:1048-1053.
M.C. Daoust, et al. (1995) "Evidence for a Third Genetic Locus for Autosomal Dominant Polycystic Kidney Disease", Genomics, 25:733-736.
M.T. Davisson, et al. (1991) "The Mouse Polycystic Kidney Disease Mutation (cpk) is Located on Proximal Chromosome 12", Genomics, 9:778-781.
I. Ebihara, et al. (1988) "Altered mRNA Expression of Basement Membrane Components in a Murine Model of Polycystic Kidney Disease", Laboratory Investigation, 58(3):262-269.
V.H. Gattone II, et al. (1991) "Murine Infantile Polycystic Kidney Disease: A Role for Reduced Renal Epidermalgrowth Factor", American Jour. of Kidney Diseases, XVII(6):606-607.
S. Golding, et al. (1995) "Tenidap-Modulated Proinflammatory Cytokine Activation of a Monocyte Cell Line", The Journal of Immunology, 154:5384-5390.
D.E. Griswold, et al. (1993) "Differentiation In Vivo of Classical Non-Steroidal Antiinflammatory Drugs from Cytokine Suppressive Antiinflammatory Drugs and Other Pharmacological Classes Using Mouse Tumour Necrosis Factor Alpha Production", Drugs Exptl. Clin. Res., XIX(6):243-248.
M.A. Harding, et al. (1991) "The SGP-2 Gene is Developmentally Regulated in the Mouse Kidney and Abnormally Expressed in Collecting Duct Cysts in Polycystic Kidney Disease", Devel. Biol. 146:483-490.
S. Horikoshi, et al. (1991) "Epidermal Growth Factor (EGF) Expression in the Congenital Polycystic Mouse Kidney", Kidney International, 39:57-62.
W.J. Kimberling, et al. (1993) "Autosomal Dominant Polycystic Kidney Disease: Localization of the Second Gene to Chromosome 4q13-q23", Genomics, 18:467-472.
J. Mandell, M.D., et al. (1993) "Animal Model of Human Disease: Congenital Polycystic Kidney Disease", Am. J. Pathol., 113(1):112-114.
D.F. Mangan, et al. (1991) "Lipopolysaccharide, Tumor Necrosis Factor-.alpha., and Il-1.beta. Prevent Programmed Cell Death (Apoptosis) in Human Peripheral Blood Monocytes.sup.1 ", The Journal of Immunology, 146:1541-1546.
R.A. McDonald, et al. (1991) "Inherited Polycystic Kidney Disease in Children", Seminars in Nephrology, 11(6):632-642.
S.A. Orellana, et al. (1995) "Epidermal Growth Factor Receptor Expression is Abnormal in Murine Polycystic Kidney", Kidney International, 47:490-499.
G.M. Preminger, M.D., et al. (1982) "Murine Congenital Polycystic Kidney Disease: A Model for Studying Development of Cystic Disease", The Journal of Urology, 127:556-560.
S.T. Reeders, et al. (1985) "A Highly Polymorphic DNA Marker Linked to Adult Polycystic Kidney Disease on Chromosome 16", Nature, 317:542-544.
M.J. Reiter, et al. (1994) "Cytokine Induction in Mice by the Immunomodulator Imiquimod", Journal of Leukocyte Biology, 55:234-240.
M. Taub, et al. (1990) "Altered Basement Membrane Protein Bosynthesis by Primary Cultures of CPK/CPK Mouse Kidney", Kidney International, 37:1090-1097.
M. Tsujimoto, et al. (1985) "Tumor Necrosis Factor: Specific Binding and Internalization in Sensitive and Resistant Cells", Proc. Natl. Acad. Sci. U.S.A.82:7626-7630.
B.B. Warner, et al. (1991) "Tumor Necrosis Factor-.alpha. Increases Mn-SOD Expression: Protection Against Oxidant Injury", The American Physiological Society, L296-L301.
G.H.W. Wong, et al. (1988) "Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism", Science, 242:941-944.
D.D.L. Woo, et al. (1994) "Taxol Inhibits Progression of Congenital Polycystic Kidney Disease", Nature, 368:750-753.
D. Woo, Ph.D. (1995) "Apoptosis and Loss of Renal Tissue in Polycystic Kidney Diseases", The New England Journal Of Medicine, 333(1):18-25.
K. Zerres, et al. (1994) "Mapping of the Gene for Autosomal Recessive Polycystic Kidney Disease (ARPKD) to Chromosome 6p21-cen", Nature Genetics, 7:429-432.
Cintins Marianne M.
Jones Dwayne C.
The Regents of the University of California
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