DNA encoing leucyl TRNA synthetase from staphylococcus aureus

Details DNA encoing leucyl TRNA synthetase from staphylococcus aureus DNA encoing leucyl TRNA synthetase from staphylococcus aureus

1997-01-17

1998-05-12

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 4352523, 43525411, 435325, 536 232, C12N 900, C12N 1500, C12N 120, C07H 2104

Patent

active

057503877

ABSTRACT:
The invention provides novel tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
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Vander Horn et al. (1992) Cloning and Nucleotide Sequence of the Leucyl-tRNA Synthetase Gene of Bacillus subtilis. J. Bacteriol. 174(12): 3928-3935.
Kron, et al., "An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase", FEBS Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc. Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Bork, et al., "Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology", Molecular Microbiology, 16(5), pp. 955-967 (1986).
Kazura, et al., "Differential Recognition of a Protective Filarial Antigen by Antibodies from Humans with Bancroftian Filariasis", J. Clin. Invest., 77, pp. 1985-1992 (1986).
Vander Horn, et al., "Cloning and nucleic acid sequence of the leucyl-tRNA-synthetase gene of Bacillus subetilis", Database EMBL, AC M88581, (1992).

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