Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-07
1998-05-12
O'Sullivan, Peter
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 91, 424 92, 435 6, 435 72, 435 724, 435 794, 435 795, 436 71, 436 86, 436129, 436172, 436503, 436504, 436548, 514 18, 5142262, 514423, 514477, 514478, 514479, 514484, 514485, 514487, 514488, 514489, 514506, 514513, 514517, 514518, 514553, 514561, 514824, 514825, 514826, 514861, 514863, 530331, 548431, 549 16, 558230, 558234, 558235, 558250, 562 26, 562 27, 564 76, G01N 3353, A61K 3140, A61K 3154, A61K 31265
Patent
active
057503516
ABSTRACT:
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
REFERENCES:
patent: 3875170 (1975-04-01), Montsumoto et al.
patent: 4056621 (1977-11-01), Brown et al.
patent: 4112104 (1978-09-01), Durant et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4670471 (1987-06-01), Clark
patent: 4868116 (1989-09-01), Morgan et al.
patent: 4870101 (1989-09-01), Ku et al.
patent: 4900750 (1990-02-01), Archibold et al.
patent: 4980286 (1990-12-01), Morgan et al.
patent: 5035878 (1991-07-01), Borch et al.
patent: 5166133 (1992-11-01), Houston et al.
patent: 5206264 (1993-04-01), Marangus
patent: 5306724 (1994-04-01), Goldberg
patent: 5380747 (1995-01-01), Medford et al.
Kurzawa and Puacz,"Determination of the stability of sodium tetramethylene dithiocarbamate in dilute aqueous solutions by means of the sodium azide-iodine reaction," Chem. Analy. (Warsaw), 23(3):417-20 (1978) (Chemical Abstracts #205007s, 89:475 (1978).
Martindale, "Disulfiram and Citrated Calcium Carbimide," The Extra Pharmacopoeia, 28th Edition, p. 579 (1985).
Neish, et al., "Functional Analysis of the Human Vascular Cell Adhesion Molecular 1 Promoter," J. Exp. Med. 176:1583-1593 (1992).
Renoux, "Imuthiol.,.RTM.," Marker Proteins Inflammation, (Proceedings of the Third Symposium, Lyon, France, Jun. 26-28, 1985) 3:591-597 (Editors J. Bienvenu, et al.; Publisher, Walter de Gruyter, Berlin-New York, 1986).
Thorn and Ludwig, The Dithiocarbamates and Related Compounds, pp. 1-298 (Publisher,Elsevier Publishing Company, Amsterdam, New York, 1962).
Ueyama, "Advancements in plant pharmacology of dithiocarbamates," Bochu Kagaku, 32(1):11-19 (1967) (Chemical Abstracts #34892g, 69:3245 (1968)).
Agrawal, et al., "Oligodeoxynucleotide phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus," Proc. Natl. Acad. Sci. USA, 85:7079-7083 (1988).
Alvarez, D.E.J., R.Montoro, et al. (1986), "Determination of cadmium, copper, and lead in sodium chloride food salts by flame atomic absorption spectroscopy," J. Assoc. Off. Anal. Chem. 68(5): 871-3.
Baselt, R.C., F.W.J., Sunderman et al. (1977), "Comparison of antidotal efficacy of sodium diethyldithiocarbamate D-penicillamine an triethylenetetramine upon acute toxicity of nickel carbonyl in rats," Res. Commun. Chem. Pathol. Pharmacol. 18(4):677-88.
Biorkhem, I.F., A. Henriksson, et al. (1991), "The antioxidant butylated hydroxytoluene protects against atherosclerosis," Arterioscler. Thromb. 11(1):15-22.
Blume, et al., "Triple helix formation by purine-rich oligonucleotides targeted to the human dihydrofolate reductase promoter," Nucl. Acids. Res., 20:1777-1784 (1992).
Brown and Langer, "Transdermal Delivery of Drugs," Annual Review of Medicine, 39:221-229 (1988).
Carew, T.E., D.C. Schwenke, et al., (1987), "Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Wantanabe heritable hyperlipidemic rabbit" Proc. Natl. Acad. Sci. U.S.A. 84(21): 7725-9.
Cooney, et al., "Site-Specific Oligonucleotide Binding Represses Transcription of the Human c-myc Gene in Vitro," Science, 241:456-459 (1988).
Corke, C.F., (1984), "The influence of diethyl-dithiocarbamate (l'Imuthiol') on mononuclear cells in vitro," Int. J. Immunoparmacol. 6(3):245-7.
Crooke, "Progress toward oligonucleotide therapeutics: pharmacodynamic properties," FASEB J., 7:533-539 (1993).
Cybulsky, et al., "Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis," Science, 251:788-791 (1991).
Donner, M., P.K. Husgafyel, et al, (1983), "Mutagenicity of rubber additives and curing fumes, Results from five short-term bioassays," Scand. J. Work Environ. Health 9(2):27-37.
Duval-Valentin, et al., "Specific inhibition of transcription by triple helix-forming oligonucelotides," Proc. Natl. Acad. Sci. USA, 89:504-508 (1992).
Eltaveb, M.A. and G.R.E. Van (1990), "Iron, copper, zinc and lead in hair from Sudanese populations of different age groups," Sci. Total Environ. 95:157-65.
Evans, R.G., J. Nielsen, et al, (1983), "Enhancement of heat sensitivity and modification of repair of potentially letal heat damage in plateu-phase cultures in mammalian cells by diethyldithiocarbamate," Radiat. Res. 93(2):319-25.
Fishbein, L. (1976), "Environmental health aspects of fungicides. I. Dithiocarbamates," J. Toxicol. Environ. Health 1(5):713-35.
Fishbeing, L. (1978), "Overview of potential mutagenic problems posed by some pesticides and their trace impuriites," Environ. Health Perspect. 27:125-31.
Fruebis, et al., "Evidence for a concerted reaction between lipid hydroperoxides and polypeptides," Proc. Natl. Acad. Sci. USA, 89:10588-10592 (1992).
Gale, G.R., A.B. Smith, et al., "Diethyldithiocarbamate in treatment of acute calmium poisoning," Ann. Clin. Lab. Sci. 11(6):476-83 (1981).
Grigoriev, et al., "A Triple Helix-forming Oligonucleotide-intercalator Conjugate Acts as a Transcriptional Repressor via Inhibition of NF kB Binding to Interleukin-2 Receptor Alpha-Regulatory Sequence," J. Biol. Chem., 267:3389-3395 (1992).
Hacker, M.P., W.b. Ershler, et al., "Effect of disulfiram (tetraethylthiuram disulfide) and diethyldithiocarbamate on the bladder toxicity and antitumor activity of cyclophosphamide in mice," Cancer Res 42(11):4490-4 (1982).
Hemavathy, K.C. and N. B. Krishnamurthy, "Cytogentic effects of Cuman L. a dithiocarbamate fungicide," Mutant Res. 208(1):57-60 (1988).
Holt, et al., "An Oligomer Complementary to c-myc mRNA Inhibits Proliferation of HL-60 Promyelocytic Cells and Induces Differentiation," Mol. Cell, Biol., 8:963-973 (1988).
Hording, Merete, P.C. Gotzsche, et al., "Lack of immunomodulating effect of disulfiram on HIV positive patients," J. Immunopharmac. 12(2):145-147 (1990).
Iademarco, et al., "Characterization of the Promoter for Vascular Cell Adhesion Molecule-1 (VCAM-1)," J. of Biol. Chem., 267(23):16232-16329 (1992).
Itakura, et al., "Synthesis and Use of Synthetic Oligonucleotides," Ann. Rev. Biochem. 53:323-356 (1984).
Inoue, K., M. Fukunaga, et al., "Effect of dilfiram and its reduced metabolite, diethyldithiocarbamate on aldehyde dehydrogenase of human erythrocytes," Life Sci. 30(5):419-24 (1982).
Jones, M.M. and M.G. Cherian, "The search for chelate antagonists for chronic cadmium intoxication," Toxicology 62(1):1-25 (1990).
Jones, S.G., M.A. Basinger, et al., "A comparison of diethyldithiocarbamate and EDTA as antidotes for acute cadmium intoxication," Res. Commun. Chem. Pathol. Pharmacol. 38(2):271-8 (1982).
Ku, G., N.S. Doherty, et al., "Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with *antioxidant* proprieties," Faseb J. 4(6):1645-53 (1990).
Lang, J.M., C. Trepo, et al., "Randomised, double-blind, placebo-controlled trial of ditocarb sodium (`Imuthiol`) in human immunodeficiency virus infection," The Lancet Sep. 24, 1988:702-706 (1988).
Lemarie, E., M. Musset, et al., "Clinical characterization of imuthiol," Methods Find Exp. Clin. Pharmacol. 8(1):51-4 (1986).
Lin, P.S., L. Kwock, et al., "Copper chelator enhancement o
Alexander R. Wayne
Khan Bobby V.
Medford Russell M.
Parthasarathy Sampath
Emory University
Haley Jacqueline
Knowles Sherry M.
O'Sullivan Peter
LandOfFree
Treatment for atherosclerosis and other cardiovascular and infla does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment for atherosclerosis and other cardiovascular and infla, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment for atherosclerosis and other cardiovascular and infla will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-978313