Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-05-30
1998-05-12
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
435 693, 935 65, A61K 39245, C12P 2102
Patent
active
057501149
ABSTRACT:
Vaccines and therapeutic compositions and methods for their production and use against Herpes Simplex Virus (HSV) are provided employing recombinant HSV glycoproteins B and D. The following E. coli HB101 strains were deposited at the A.T.C.C., where the plasmid indicates the plasmid employed to transform the strain; pHS203; pHS112; pHS114; pHS127A and pHS206 were deposited on Apr. 4, 1984, and assigned Accession Nos. 39649-39653, respectively; pYHS109 and pYHS118 were deposited on Jul. 11, 1984, and given Accession Nos. 39762 and 39763, respectively.
REFERENCES:
patent: 4374127 (1983-02-01), Larson et al.
patent: 4618578 (1986-10-01), Burke et al.
patent: 4642333 (1987-02-01), Person
patent: 4661349 (1987-04-01), Kino et al.
patent: 4724126 (1988-02-01), Kino et al.
patent: 4762708 (1988-08-01), Cohen et al.
patent: 4818694 (1989-04-01), Watson et al.
patent: 4855224 (1989-08-01), Berman et al.
patent: 4891315 (1990-01-01), Watson et al.
patent: 5171568 (1992-12-01), Burke et al.
patent: 5244792 (1993-09-01), Burke et al.
Berman et al. "Detection of Antibodies to Herpes Simplex Virus with a Continuous Cell Line Expressing Cloned Glycoprotein D" Science (1982) 222:524-527.
Berman et al. "Protection from genital herpes simplex virus type 2 infection by vaccination with cloned type 1 glycoprotein D" Science (1985) 227:1490-1492.
Blacklaws et al. "Immunogenicity of Herpes Simplex Virus Type 1 Glycoproteins Expressed in Vaccinia Virus Recombinants" Virology (1990) 177:727-736.
Bzik et al. "Nucleotide Sequence Specifyin the Glycoprotein Gene, gB, of Herpes Simplex Virus Type 1" Virology (1984) 133:301-314.
Cappel et al. "Clinical Efficacy of a Herpes Simplex Subunit Vaccine" J. Medical. Virol. (1985) 16:137-145.
Chan "Protective immunization of mice with specific HSV-1 glycoproteins" Immunology (1983) 49:343-352.
Cohen et al. "Localization and Synthesis of an Antigenic Determinant of Herpes Simplex Virus Glycoprotein D that Stimulates the Production of Neutralizing Antibody" J. Virol. (1984) 49:102-108.
DeLuca et al. "Nucleotide Sequences of Herpes Simplex Virus Type 1 (HSV-1) Affecting Virus Entry, Cell Fusion, and Production of Glycoprotein gB (VP7)" Virology (1982) 122:411-423.
Dundarov et al. "Immunotherapy with Inactivated Polyvalent Herpes Vaccines" Devel. Biol. Standard. (1982) 52:351-357.
Eberle et al. "Relative Titers of Antibodies to Individual Polypeptide Antigens of Herpes Simplex Virus Type 1 in Human Sera" J. Infect. Dis. (1983) 148(3):436-444.
Hilfenhaus et al. "Herpes Simplex Virus Subunit Vaccine: Characterization of the Virus Strain Used and Testing of the Vaccine" Devel. Biol. Standard. (1982) 52:321-331.
Kutinova et al. "Placebo-controlled study with subunit herpes simplex virus vaccine in subjects suffering from frequent herpetic recurrences" Vaccine (1988) 6:223-228.
Lasky et al. "Protection of Mice from Lethal Herpes Simplex Virus Infection by Vaccination with a Secreted Form of Clones Glycoprotein D" Biotechnology (Jun. 1984) pp. 527-532.
Marsden et al. "Physical Mapping of Herpes Simplex Virus-Induced Polypeptides" J. Virol. (1978) 28(2):624-642.
Mertz et al. "Double-blind placebo-controlled trial of a herpes simples virus type-2 glycoprotein vaccine in persons at high risk of genital herpes infection" J. Infect. Dis.(1990) 161:653-660.
Pellett et al. "Anatomy of the herpes simplex virus 1 strain F glycoprotein B gene: primary sequence and predicted protein structure of the wild type and of monoclonal antibody resistant mutants" J. Virol. (1985) 53(1):243-253.
Roizman et al. "The Organization of the Herpes Simplex Virus Genomes" Ann. Rev. Genetics (1979) 13:25-57.
Roizman et al. "Application of Molecular Genetics to the Design of Live Herpes Simplex Virus Vaccines" Devel. Biol. Standard. (1982) 52:287-304.
Ruyechan et al. "Molecular genetics of herpes simplex virus. II. Mapping of the major viral glycoproteins and of the genetic loci specifying the social behavior of infected cells" J. Virol. (1979) 29(2):677-697.
Skare et al. "Structure and Function of Herpesvirus Genomes" Virology (1977) 76:581-595.
Skinner et al. "Follow-up report on 50 subjects vaccinated against Herpes genitalis with Skinner vaccine" Med. Microbiol. Immunol. (1987) 176:161-168.
Skinner et al. "Early Experience with `Antigenoid` Vaccine AcNFU.sub.1 (S.sup.-)MRC Towards Prevention or Modification of Herpes Genitalis" Devel. Biol. Standard. (1982) 52:333-344.
Stanberry, et al. "Genital Herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent disease" J. of Infect. Dis. (1982) 146(3):397-404.
Stanberry et al. "Recombinant herpes simplex virus glycoproteins: protection against initial and recurrent genital herpes" J. Infect. Dis. (1987) 155(5):914-920.
Stanberry et al. "Preinfection Prophylaxis with Herpes Simplex Virus Glycoprotein Immunogens: Factors Influencing Efficacy" J. Gen. Virol. (1989) 70:3177-3185.
Stanberry, L.R. "Pathogenesis of Herpes Simplex Virus Infection and Animal Models for Its Study" Current Topics in Microbiology and Immunology (1992) 179:16-30.
Watson et al. "Herpes simplex virus type 1 glycoprotein D gene: nucleotide sequence and expression in Escherichia coli " Science (1982) 218:381-384.
Weis et al. "An immunologically active chimaeric protein containing herpes simplex virus type 1 glycoprotein D" Nature (1983) 302:72-74.
Burke Rae Lyn
Pachl Carol
Valenzuela Pablo D. T.
Blackburn Robert P.
Chiron Corporation
McClung Barbara G.
Mosher Mary E.
Robins Roberta L.
LandOfFree
Recombinant herpes simplex gB-gD vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant herpes simplex gB-gD vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant herpes simplex gB-gD vaccine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-976921