Stable hydrazones linked to a peptide moiety as reagents for the

Details Stable hydrazones linked to a peptide moiety as reagents for the Stable hydrazones linked to a peptide moiety as reagents for the

1995-06-07

1998-05-12

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 141, 530300, 530317, 530323, 530332, 544238, 546281, A61K 5108, A61K 3800, C07D40100

Patent

active

057500886

ABSTRACT:
This invention provides novel reagents for the preparation of radiopharmaceuticals useful as imaging agents for the diagnosis of cardiovascular disorders, infection, inflammation and cancer, diagnostic kits comprising said reagents and intermediate compounds useful for the preparation of said reagents. The reagents are comprised of stable hydrazone modified biologically active molecules that react with gamma emitting radioisotopes to form radiopharmaceuticals that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy.

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