Alkali metal and alkaline earth metal salts of benzoylacetonitri

Details Alkali metal and alkaline earth metal salts of benzoylacetonitri Alkali metal and alkaline earth metal salts of benzoylacetonitri

1978-05-09

1980-04-08

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2603265R, 260429R, 2604299, 2604381, 260439R, 260448R, 260465E, 260465F, 42424857, 424250, 424267, 424274, 424287, 424289, 424294, 424295, 544107, 544398, 546230, A61K 31275, A61K 3128, A61K 3133

Patent

active

041973127

ABSTRACT:
This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being the pharmacologically acceptable cationic salts of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile, or mixtures thereof.

REFERENCES:
patent: 3763285 (1973-10-01), Riebel et al.
patent: 3775517 (1973-11-01), Riebel et al.
patent: 4083993 (1978-04-01), Sloboda et al.
Dorsch et al., J.A.C.S., 54 (1932), pp. 2960-2964.
C.A., 69 (1968), Pihl et al., 100208s.
Nakanishi et al., J. Med. Chem., 16(3), 1973, pp. 214-219.

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