Method of reducing pre-and post-ischemic myocardial arrhythmias

Details Method of reducing pre-and post-ischemic myocardial arrhythmias Method of reducing pre-and post-ischemic myocardial arrhythmias

Filed on

1989-12-18

Date issued

1990-10-09

Examiner

Gerstl, Robert

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Phosphorus containing other than solely as part of an...

Other Related Categories

A61K 31675

Type

Patent

Status

active

Patent number

049620959

Description

ABSTRACT:
Zofenopril, fosinopril, (S)-1-[6-amino-2-[[hydroxy (4-phenylbutyl) phosphinyl]oxy]-1-oxohexyl]-L-proline or a pharmaceutically acceptable salt thereof alone or in combination with a thrombolytic, antiarrhythmic, or antifibrillatory agent is employed to reduce pre-and post- ischemic myocardial arrhythmias and fibrillations as well as reducing arrhythmias associated with congestive heart failure.

REFERENCES:
patent: 4745196 (1988-05-01), Karanewsky et al.
patent: 4808413 (1989-01-01), Joshi et al.
Rochette et al., "Protective Effect of ACE Inhibitors . . . "Clin. and Exper.-Theory and Practice, A9 (2&3), 365-368 (1987).
Westlin et al., "Does Captopril Attenuate Reperfusion-Induced Myocardial Dysfunction by Scavenging Free Radicals?", Circulation, vol. 77 (Suppl I), pp. 30-39, Jun. 1988.
van Gilst et al., "Reduction of Reperfusion Arrhythmias in the Ischemic Isolated Rat Heart by ACE Inhibitors . . . ", J. Cardiovacs Pharmacol, vol. 8, No. 4, 722-728, 1986.
Li et al., "Protective Effects of Captopril and Enalopril on Myocardial Ischemia and Reperfusion Damage of Rat", J. Mol. Cardiol, vol. 19, pp. 909-915 (1987).
van Gilst et al., "Captopril Reduces Purine Loss and Reperfusion Arrhythmi in the Rat Heart after Coronary Artery Occulsion, " European Jour. of Pharmacology, vol. 100, pp. 113-117 (1984).
De Graeff et al., "Concentration-Dependent Protection by Captopril Against Ischemia-Reperfusion Injury in the Isolated Rat Heart", Arch., int. Pharmacodyn., vol. 280, pp. 181-193 (1986).
De Graeff et al. "Concentration-Dependent Protection by Captopril Against Myocardial Damage During Ischemia and Reperfusion in a Closed Chest Pig Model", Jour of Cardiovascular Pharmacology, 9 (Suppl. 2) pp. S37-42 (1987).

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