Analgesic mixture of nalbuphine and zomepirac

Details Analgesic mixture of nalbuphine and zomepirac Analgesic mixture of nalbuphine and zomepirac

1982-06-30

1983-10-04

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424274, A61U 3140, A61U 31485

Patent

active

044078056

ABSTRACT:
Pharmaceutical compositions of nalbuphine and zomepirac have been found to exhibit unexpectedly enhanced analgesic activity by applying an analysis model which considers data characterizing the analgesic effect of both the pure components as well as the fixed dose ratio combinations. This synergism enables the use of lower doses of either or both drugs with a concomitant reduction in risk of possible side effects.

REFERENCES:
patent: 3393197 (1968-07-01), Pachter et al.
patent: 4132788 (1979-01-01), Wong
patent: 4237140 (1980-12-01), Dudzinski
patent: 4282215 (1981-08-01), Dudzinski et al.
patent: 4322427 (1982-03-01), Buyniski
New Drug Commentary, 8(5), May 1981.

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