Anti-ischemic pharmaceutic compositions

Details Anti-ischemic pharmaceutic compositions Anti-ischemic pharmaceutic compositions

1981-09-28

1983-10-04

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424180, A61K 31495, A61K 3170

Patent

active

044078013

ABSTRACT:
The subject of the invention is a novel pharmaceutical composition, especially having an anti-ischaemic action, containing, in combination, a high dosage (within the range of from 20 to 80 mg) of the dihydrochloride (or another mineral or organic salt) of 1-(2,3,4-trimethoxybenzyl)piperazine and a disintegrating agent, such as mannitol or sodium carboxymethyl starch, that has the effect of liberating the salt of 1-(2,3,4-trimethoxybenzyl)piperazine virtually instantaneously in the organism, this composition being, furthermore, advantageously enclosed in a thin coating film or held together by a binder that is itself readily disintegrated in situ in the organism in such a manner that it makes possible a "flash" action, that is to say a virtually instantaneous action, of the above-mentioned salt in situ. This composition is administered to the patient at a dosage of from 20 to 80 mg/day.

REFERENCES:
patent: 3262852 (1966-07-01), Servier
Mehrotra, T. et al., Brit. J. Clin. Pract., 21(11), 553 (1967).
Brodbin, P. et al., Brit. J. Clin. Pract., 22(9), 395 (1968).
Saito, D., Japan Circ. J., 40, 363, (1976).

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