Conformationally restricted mimetics of beta turns and beta bulg

Details Conformationally restricted mimetics of beta turns and beta bulg Conformationally restricted mimetics of beta turns and beta bulg

1994-03-09

1995-08-08

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530323, 530333, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

054400139

ABSTRACT:
The invention provides materials and methods for synthesizing novel beta-turn mimetics, as well as the novel beta-turn mimetics themselves, and peptides containing the same. Also provided are novel synthetic nonpeptide therapeutic molecules designed upon the interactions between beta-turn mimetics or peptides containing the same, and receptors or enzymes.

REFERENCES:
Kahn et al. JACS vol. 110 1638-1639 (1988).
Kahn et al. Tetrahedron Letters vol. 30 No. 18, 2317-2320 (1989).
Kahn et al. J. Mol. Recog vol. 1:75-79 (1988).
Miller et al. JACS vol. 102, 7026-7032 (1980).
Freidinger et al. Science vol. 210 656-658 (Nov. 1980).
Marshall et al., Ann. Rep. Med. Chem. 13: 227-238 (1978).
Hruby, Trends Pharmacol. Sci. 8: 336-339 (1987).
Chipkin et al., Ann. Rep. Med. Chem. 23: 11 (1988).
Romer et al., Nature 298: 759 (1982).
Ferreira et al., Biochemistry 9: 2583 (1970).
Chang et al., Science 230: 177 (1985).
Friedinger et al., Science 210: 656-658 (1980).
Krstenasky et al., Biochem. Biophys. Comm. 109: 1368-1374 (1982).
Kahn et al., Tetrahedron Lett. 27: 4841-4844 (1986).
Vallee et al., Int. J. Pept. Prot. Res. 33: 181-190 (1989).
Kahn et al., Heterocycles 25: 29-31 (1987).
Kahn et al., Tetrahedron Lett. 28: 1623-1626 (1987).
Kahn et al., J. Am. Chem. Soc. 110: 1638-1639 (1988).
Kahn et al., J. Mol. Recogn. 1: 75-79 (1988).
Kemp et al., Tetrahedron Lett. 29: 5057-5060 (1988).
Arrhemius et al., Proc. Am. Peptide Symp., Rivier and Marshall, Eds. Escom. Leiden (1990).
Hruby et al., Biochem. J. 268: 249-262 (1990).
Ball et al., J. Mol. Recogn. 3: 55-64 (1990).
Morgan et al., Ann. Rep. Med. Chem. 24: 243-252 (1989).
Fauchere, Adv. Drug Res. 15: 29-69 (1986).
Hoffman and Kim, Tetrahedron Lett. 31: 2953 (1990).
Gribble and Nutaitis, Org. Prep. Proced. Inc. 17: 317, A85.
Sasaki and Coy, Peptides 8: 119 (1987).
Hart and Ha, Chem. Rev. 89: 1447 (1989).
Salzman et al., J. Am. Chem. Soc. 102: 6161 (1980).
Miller et al., J. Am. Chem. Soc. 102: 7026 (1980).
Williams et al., J. Amer. Chem. Soc. 111: 1073 (1989).
Goel et al., Org. Syn. 67: 69 (1988).
House and Rasmusson, J. Org. Chem. 26: 4278 (1961).
Corey and Fuchs, Tetrahedron Lett. 36: 3769 (12972).
Lindlar, Helv. Chim. Acta. 35: 446 (1952).
Satterthwait et al., Chem. Abst. 112: 179892y (1990).
Sargovi et al., Science 253: 792-793 (1991).
Kahn, et al., J. Mol. Recogn. 1: 75-79 (1988).

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