Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1993-02-09
1995-08-08
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514678, 514681, 514691, A61K 3122, A61K 3112
Patent
active
054399360
ABSTRACT:
A therapeutic method is provided to inhibit tumor cell growth in a subject in need of said therapy is provided, comprising parenterally administering a therapeutic amount of a compound in a pharmaceutically acceptable carrier, wherein said compound has the structure: ##STR1## wherein R is selected from the group consisting of: ##STR2## and wherein said tumor cell is sensitive to inhibition by said compound and is selected from the group consisting of a myeloid leukemia cell, a T-cell leukemia cell, a lung carcinoma cell, an ovarian carcinoma cell, and a breast carcinoma cell.
REFERENCES:
Anchel et al., "The Biogenesis of Illudins S and M In Clitocybe Illudens*" Phytochemistry 9:2339-2343 (1970).
Anchel et al., "Antibiotic Substances From Basidiomycetes. VIII. Clitocybe Illudens*" Proc. Natl. Acad. Sci. USA 36(5):300-305 (1950).
Bransteterova et al., "HPLC determination of a new anticancer agent (acylfulvene) in serum*" Neoplasma 39(6):369-373 (1992).
Brandsteterova et al., "HPLC Analysis of Novel Anti-Cancer Agents-Illudins and Their Analogs" J. Liquid chromatography 16(1):115-125 (1993).
French et al., "Poisoning With The North American Jack O'Lantern Mushroom" Clinical Toxicology 26(1&2):81-88 (1988).
Hanson et al., "Studies in Terpenoid Biosynthesis. Part XV. Biosynthesis of the Sesquiterpenoid Illudin M" J.C.S. Perkin I 876-880 (1976).
Harttig et al., "Leaianafulvene, A Sesquiterpenoid Fulvene Derivative From Cultures of Mycena Leaiana*" Phytochemistry 29(12):3942-3944 (1990).
Kelner et al., "Preclinical Evaluation of Illudins as Anticancer Agents" Cancer Research 47:3186-3189 (1987).
Kelner et al., "Preclinical Evalution of Illudins as Anticancer Agents: Basis for Selective Cytotoxicity" J. Natl. Cancer Inst. 82(19):1562-1565 (1990).
McMorris et al., "On the Mechanism of Toxicity of Illudins: The Role of Glutathione" Chem. Res. Toxicol. 3(6):574-579 (1990).
McMorris et al., "Fungal Metabolites. The Structures of the Novel Sesquiterpenoids Illudin-S and M" J. Amer. Chemi. Society 87(7):1594-1600 (1965).
McMorris et al., "Structure-Activity Relationships of Illudins: Analogs with Improved Therapeutic Index" J. Org. Chem. 57(25):6876-6883 (1992).
McMorris et al., "Structure and Reactivity of Illudins" Tetrahedron 45(17):5433-5440 (1989).
Shimomura, Osamu, "The Role of Superoxide Dismutase in Regulating the Light Emission of Luminescent Fungi" J. of Experimental Botany 43(256):1519-1525 (1992).
Tanaka et al., "Metabolism of illudin S, a toxic principle of Lampteromyces japonicus, by rat liver. I. Isolation and identification of cyclopropane ring-cleavage metabolites" Xenobiotica 20(7):671-681 (1990).
Tanaka et al., "Metabolism by rat liver cytosol of illudin S, a toxic substance of Lampteromyces japonicus. II. Characterization of illudin s-metabolizing enzyme" Xenobiotica 22(1):33-39 (1992).
Varki et al., "Cloned Low Metastatic Variants from Human Lung Carcinoma Metastases" Anticancer Research 10:637-644 (1990).
Walser et al., "Mode of Action of Illudin S" Antimicrob. Ag. Chemother. 3(3):357-362 (1973).
Weinreb, S. M., "Fulvenes Derived From Illudin S" Tetrahedron Ltrs. 38:3489-3491 (1971).
Kelner Michael J.
McMorris Trevor C.
Taetle Raymond
Goldberg Jerome D.
The Regents of the University of California
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