Hydroxy substituted ureido amino and imino acids

Details Hydroxy substituted ureido amino and imino acids Hydroxy substituted ureido amino and imino acids

1984-03-30

1986-08-05

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514339, 514341, 514343, 514397, 514414, 514423, 546147, 546256, 546268, 546273, 546276, 546281, 548188, 548336, 548356, 548454, 548455, 548456, 548463, 548467, 548468, 548517, 548525, 548527, 548533, 548534, 548409, 548953, 560 34, 560 16, 562439, 562426, C07D20704, C07D20720, A61K 3140, A61K 3144

Patent

active

046044027

ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

REFERENCES:
patent: 4402969 (1983-09-01), Greenlee et al.
patent: 4470973 (1984-09-01), Natarajan et al.
patent: 4474778 (1984-10-01), Gordon et al.
patent: 4500518 (1985-02-01), Gordon et al.
patent: 4514391 (1985-04-01), Gordon et al.
Meyer et al., "Angiotensin Converting Enzyme Inhibitors . . . " J. Med. Chem., vol. 25, pp. 996-999 (1982).

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