Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-09-03
1986-08-05
Jiles, Henry H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 65, 546 80, 546 89, A61K 3138, A61K 31395, C07D49102, C07D47102
Patent
active
046043977
ABSTRACT:
Disclosed are the compounds of formula I ##STR1## wherein X represents oxygen or sulfur; ring A is unsubstituted or substituted by one to three identical or different substituents selected from hydroxy, hydroxy-lower alkyl, etherified hydroxy, etherified hydroxy-lower alkyl, acyloxy, acyloxy-lower alkyl, halogen, lower alkyl, trifluoromethyl, amino, mono- and di-lower alkylamino and acylamino; or ring A is substituted by one lower alkylenedioxy; R represents hydrogen, lower alkyl or aryl-lower alkyl; R.sub.1 represents hydrogen, lower alkyl, lower alkylthio-lower alkyl, amino, acylamino, (amino, mono- or di-lower alkylamino)-lower alkyl, carboxy, lower alkoxycarbonyl, carbamoyl or mono- or di-lower alkylcarbamoyl; R.sub.2 to R.sub.5 represent hydrogen or lower alkyl; the dehydro derivatives thereof with a double bond at the 1,2-position, or at the 1,10b-position in which case R.sub.5 is absent; or a pharmaceutically acceptable salt thereof; methods for their synthesis; pharmaceutical compositions thereof; and use thereof as psychactive agents for the treatment of central nervous system disorders.
REFERENCES:
patent: 3689497 (1972-09-01), Brown
patent: 3915996 (1975-10-01), Wright et al.
patent: 4025630 (1977-05-01), Dren et al.
patent: 4198511 (1980-04-01), Connor
patent: 4210758 (1980-07-01), Connor
patent: 4292316 (1981-09-01), Dren et al.
patent: 4385056 (1983-05-01), Loosen
patent: 4420480 (1983-12-01), Jones
patent: 4540691 (1985-09-01), Horn
J. Med. Chem. 25 925/(1982).
Abstract European Patent 99 303.
Ciba-Geigy Corporation
Gruenfeld Norbert
Jiles Henry H.
Richter J.
LandOfFree
Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-969340