Method of preparing stable sterile crystalline cephalosporins fo

Details Method of preparing stable sterile crystalline cephalosporins fo Method of preparing stable sterile crystalline cephalosporins fo

1975-04-11

1977-06-14

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

53 25, 424246, C07D50112

Patent

active

040296555

ABSTRACT:
Sterile, essentially crystalline cephalosporins for parenteral administration are prepared by a freeze-drying process wherein, after rapidly cooling a solution of such cephalosporins to at least -15.degree. C. in no more than 3 hours, the frozen solution is held between about <0.degree. C. and about -10.degree. C. until the nucleation of the cephalosporin is substantially complete before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.

REFERENCES:
the Merck Index, p. 222, (Eighth Edition 1968).

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