Anti-atherosclerotic peptides and a transgenic mouse model of an

Details Anti-atherosclerotic peptides and a transgenic mouse model of an Anti-atherosclerotic peptides and a transgenic mouse model of an

1997-09-05

2000-12-05

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3800, C07K 500

Patent

active

061567272

ABSTRACT:
The present invention provides an anti-atherosclerotic peptide, said peptide being an amphipathic helical peptide compared with human apoA-I, characterized by having at least 4 of the following 8 properties: a tandem repeating class A amphipathic helix linked by a proline which forms an optimal arrangement for lipid association, has bilayer membrane stabilizing properties, stimulates HIV-I Gp41-induced cell fusion, stimulates neutrophil activation, stimulates BSA-induced lysis of fatty acid-containing vesicles, stimulates human placental lactogen synthesis, effluxes phospholipid and cellular cholesterol from cholesterol-loaded cells, and competes with HDL for binding to cells. The present invention is also directed to pharmaceutical compositions, transgenic animals expressing a protein disclosed herein, vectors expressing such proteins.

REFERENCES:
patent: 4643988 (1987-02-01), Segrest et al.
Tytler et al. Synthetic peptides in the study of viral fusion, inflammation, and athersclerosis. In: Peptides: design, synthesis, and biological activity. Basava and Anantharamaiah, editors, p. 113-132, 1994.

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