Optically active benzoquinolizine compounds, process for prepari

Details Optically active benzoquinolizine compounds, process for prepari Optically active benzoquinolizine compounds, process for prepari

1988-12-19

1990-08-07

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544361, 546 95, A61K 31495, A61K 31435, C07D45504

Patent

active

049468448

ABSTRACT:
An optically active (+)-isomer of a benzoquinolizine compound of the formula [I], is provided: ##STR1## where X.sub.1 represents a halogen atom, and R.sub.1 and R.sub.2 represent lower alkyl groups, a physiologically acceptable salt thereof, or a hydrate of either of the foregoing compounds. The compounds [I]-(+) exhibit an excellent antibacterial activity. Also, the compounds exhibit high solubility in water. Therefore, the compounds of the present invention are usable for the treatment of infectious diseases and usable in aqueous liquid preparations such as injections.

REFERENCES:
patent: 4117229 (1978-09-01), Baker et al.
patent: 4195176 (1980-03-01), Baker et al.
patent: 4683341 (1987-07-01), Ishii et al.
patent: 4720495 (1988-01-01), Takagi et al.
patent: 4818394 (1989-04-01), Okamoto et al.

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