Phosphonic acid substituted steroids as steroid 5.alpha.-reducta

Details Phosphonic acid substituted steroids as steroid 5.alpha.-reducta Phosphonic acid substituted steroids as steroid 5.alpha.-reducta

1988-12-23

1990-08-07

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 75, 514120, 514130, 514134, 424601, 540 23, 540 95, 540100, 540 5, 552506, 552611, 552505, 552607, 552609, 552599, 552603, 552636, 552640, 552633, 552539, 552610, A61K 3166, C07J 100, C07J 4300

Patent

active

049468340

ABSTRACT:
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5.alpha.-reductase. Also invented are intermediates used in preparing these compounds.

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patent: 4361578 (1982-11-01), Alig et al.
patent: 4377584 (1983-03-01), Rasmusson et al.
Hsia and Voight, J. Invest. Dermat., 62:224-227 (1973).
Robaire et al., J. Steroid Biochem., 8:307-310 (1977).
Blohm, T. R., et al., Biochem. Biophys. Res. Comm. 95:273-280 (1980).
Liang, T., et al., J. Steriod Biochm. 19, 385-390 (1983).
Petrow, V., et al., Steroids 38:121-140 (1981).
Brooks et al., Steroids: 47:1-19 (Jan. 1986).

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