Multitrophic and multifunctional chimeric neurotrophic factors,

Details Multitrophic and multifunctional chimeric neurotrophic factors, Multitrophic and multifunctional chimeric neurotrophic factors,

1990-08-08

1992-12-08

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 536 27, 530399, 530402, 530839, 514 12, C12P 2102, C12N 1518, C07H 1702, C07K 1300

Patent

active

051697645

ABSTRACT:
The present invention relates to chimeric neurotrophic factors which comprise at least a portion of a naturally occurring cellular factor and a portion of at least one other molecule such that the resulting chimeric molecule has neurotrophic activity. It is based, in part, on the discovery that chimeric molecules comprising portions of both NGF and BDNF are likely to possess neurotrotrophic activity, and in some cases exhibit a spectrum of activity larger than that of either parent molecule. It is further based on the discovery that chimeric molecules comprising neurotrophic factor sequences as well as additional peptide sequences may retain neurotrophic activity, and in some cases may exhibit a more potent activity than the parent factor. The chimeric neurotrophic factor molecules of the invention provide a number of advantages relative to naturally occurring neurotrophic factors. Chimeric neurotrophic factors may be used to provide, for example, the activity of two neurotrophic factors in a single molecule, or may serve as superagonists of an endogenous neurotrophic factor, thereby enabling an increased biological response at lower doses. Nucleic acids and plasmids encoding the chimeras are disclosed.

REFERENCES:
patent: 4414150 (1983-11-01), Goeddel
patent: 4725536 (1988-02-01), Fritsch et al.
patent: 4855406 (1989-08-01), Yanaihara et al.
Hohn et al., Nature 344: 339-341, Mar. 22, 1990.
Leibrock et al., Nature 341: 149-152, Sep. 14, 1989.
Dicou et al., J. Neurosci. Res. 22: 13-19, 1989.
J. Scott et al., Nature 302: 538-540, Apr. 7, 1983.
A. Ullrich et al., Nature 303: 821-825, Jun. 30, 1983.
G. E. Schulz et al., Principles of Protein Structure, 1979, pp. 14-16.
E. Kanaya et al., Gene 83: 65-74, 1989.
E. Dicou et al., J. Neurosci. Res. 22: 13-19, 1989, as abstracted in Biological Abstracts 87: AB-746, 1989.
C. F. Ibanez et al., Embo Journal 9: 1477-1483, 1990.
Schulz et al., Protein Structure and Function, 1979, pp. 14-16.

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